Cosmetic compositions

ABSTRACT

Disclosed are compositions and methods for their use that can be used individually or in combination. The compositions have the ability to treat a wide range of skin and skin conditions, and particularly men&#39;s skin.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No.15/893,339 filed Feb. 9, 2018, which is a divisional of U.S. patentapplication Ser. No. 14/527,435 (U.S. Pat. No. 9,937,119) filed Oct. 29,2014, which claims the benefit of U.S. Provisional Application No.61/896,975, filed Oct. 29, 2013. The contents of each of the referencedapplication are incorporated herein by reference.

BACKGROUND OF THE INVENTION A. Field of the Invention

The present invention relates generally to various skin formulationsthat are structured in such a way to treat a wide range of conditions inmale skin. The formulations can be used separately or in combination.

B. Description of Related Art

There are thousands of skin formulations available to consumers. Inaddition, the skin of men has different needs from the skin of womenand, while women have a large selection of skincare products to choosefrom, the options available formulated specifically for men are muchfewer. This leaves them with the choice of having to identify one of alarge number of female-designed products or of selecting from a narrowerrange of products designed for male skin, which results in a confusingand exhaustive search for different products for different applications.

SUMMARY OF THE INVENTION

The various formulations discovered by the inventors can be used on alltypes of skin. In particular aspects, however, the formulations workparticularly well on men's skin. Further, when the formulations are usedin combination, additional benefits can be obtained. The formulationsmay be creams, and may be capable of moisturizing skin, treating theskin around the eyes, or cleansing the skin.

In one instance, there is disclosed a topical skin composition that iscapable of moisturizing skin and treating the skin around the eyescomprising any one of, any combination of, or all of water, glycerin,butylene glycol, ethylene/acrylic acid copolymer, Butyrospermum parkiibutter, disodium EDTA, and triethanolamine. The amounts of theingredients within the composition can vary (e.g., amounts can be as lowas 0.000001% to as high as 70% w/w or any range therein). In oneinstance, the composition includes 25% to 70% w/w of water, 1% to 10%w/w of glycerin, 0.5% to 6% w/w of butylene glycol, 0.5% to 3% w/w ofethylene/acrylic acid copolymer, 0.5% to 5% w/w of Butyrospermum parkiibutter, 0.01% to 0.2% w/w of disodium EDTA, and 0.05% to 1% w/w oftriethanolamine.

In another aspect, there is disclosed a topical skin composition that isformulated as a cream and has a sun protection factor of around 30comprising any one of, any combination of, or all of oxybenzone,octisalate, octocrylene, homosalate, avobenzone, styrene/acrylatescopolymer, water, glycerin, butylene glycol, ethylene/acrylic acidcopolymer, Butyrospermum parkii butter, disodium EDTA, andtriethanolamine. The composition can further include any one of, anycombination of, or all of: glycereth-26, allantoin, xantham gum,panthenol, tocopherol acetate, sodium PCA, benzyl alcohol, PEG-100stearate, lauramine oxide, C9-15 alkyl phosphate,polymethylsilsesquioxane, methyl trimethicone, acrylates/dimethiconecopolymer, trisiloxane, cetearyl alcohol, C12-15 alkyl benzoate,phenethyl benzoate, polyester-7, ceteth-20 phosphate, neopentyl glycoldiheptanoate, dimethicone, dipropylene glycol dibenzoate, dicetylphosphate, caprylyl glycol, methyl trimethicone, methyldihydrojasmonate,hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer,pentylene glycol, squalane, ethylene brassylate, ethyl linalool, PPG-15stearyl ether benzoate, sorbic acid, polysorbate 60, isobutyl methyltetrahydropyranol, trimethylbenzenepropanol, sorbitan isostearate,phenylisohexanol, ammonium hydroxide, glyceryl stearate, arachidylalcohol, potassium cetyl phosphate, steareth-21, hydrogenated palmglycerides, behenyl alcohol, arachidyl glucoside, hydrogenated lecithin,benzyl alcohol, hydroxyethyl acrylate/sodium acryloydimethyl tauratecopolymer, C9-15 alkyl phosphate, tocopheryl acetate, phenoxyethanol,ceteryl alcohol, trimethypentanediol/adipic acid/glycerin crosspolymer,isobutyl methyl tetrahydropryranol, adenosine, and sodium benzoate. Thecomposition can further include Opuntia tuna fruit extract. The amountsof the ingredients within the composition can vary (e.g., amounts can beas low as 0.000001% to as high as 70% w/w or any range therein). In oneinstance, the composition includes 25% to 70% w/w of water, 1% to 10%w/w of glycerin, 0.5% to 6% w/w of butylene glycol, 0.5% to 3% w/w ofethylene/acrylic acid copolymer, 0.5% to 5% w/w of Butyrospermum parkiibutter, 0.01% to 0.2% w/w of disodium EDTA, 0.05% to 1% w/w oftriethanolamine, and 15% to 30% w/w of a combination of oxybenzone,octisalate, octocrylene, homosalate, avobenzone, and styrene/acrylatescopolymer. In some embodiments, the compositions may comprise 0.0001% to0.1% w/w of Opuntia tuna fruit extract. Also contemplated is a method ofprotecting skin from UV radiation comprising topically applying thecomposition to skin in need thereof, wherein topical application of saidcomposition protects the skin from UV radiation.

In yet another aspect, there is disclosed a topical skin compositionformulated as a cream capable of reducing the appearance of dark circlesor puffy eyes comprising any one of, any combination of, or all ofwater, glycerin, butylene glycol, ethylene/acrylic acid copolymer,Butyrospermum parkii butter, disodium EDTA, and triethanolamine. Thecomposition can further include any one of, any combination of, or allof phenoxyethanol, Carbopol Ultrez 10 (carbomer), cetearyl glucoside,chlorphenesin, adenosine, betaine, Hispagel 200 NS (glycerin andglyceryl polyacrylate), cetearyl alcohol, ceteareth-20, C12-15 alcoholsbenzoate, hydrogenated polydecene, polyethylene, cetyl esters, behenylalcohol, eldew PS-304 (phytosteryl/behenyl/octyldodecyl lauroylglutamate), dipalmit hydroxyproline, dimethicone silicone, Glycacil 2000(iodopropynyl butylcarbamate), and palmitoyl tetrapeptide-7. Thecomposition can further include Opuntia tuna fruit extract. The amountsof the ingredients within the composition can vary (e.g., amounts can beas low as 0.000001% to as high as 70% w/w or any range therein). In oneinstance, the composition includes 25% to 70% w/w of water, 1% to 10%w/w of glycerin, 0.5% to 6% w/w of butylene glycol, 0.5% to 3% w/w ofethylene/acrylic acid copolymer, 0.5% to 5% w/w of Butyrospermum parkiibutter, 0.01% to 0.2% w/w of disodium EDTA, 0.05% to 1% w/w oftriethanolamine, 0.5% to 1.5% w/w of phenoxyethanol, 0.2% to 0.4% w/w ofCarbopol Ultrez 10 (carbomer), 0.5% to 1.5% w/w of cetearyl glucoside,0.2% to 0.3% w/w of chlorphenesin, 0.01% to 0.1% w/w of adenosine, 1.0%to 5.0% w/w of betaine, 2.0% to 3.0% w/w of Hispagel 200 NS (glycerinand glyceryl polyacrylate), 0.25% to 1.5% w/w of cetearyl alcohol, 0.25%to 1.5% w/w of ceteareth-20, 2.0% to 4.0% w/w of C12-15 alcoholsbenzoate, 2.0% to 3.0% w/w of hydrogenated polydecene, 2.0% to 3.0% w/wof polyethylene, 1.0% to 1.5% w/w of cetyl esters, 1.0% to 1.5% w/w ofbehenyl alcohol, 0.25% to 1.0% w/w of eldew PS-304(phytosteryl/behenyl/octyldodecyl lauroyl glutamate), 0.25% to 1.0% w/wof dipalmit hydroxyproline, 0.5% to 1.5% w/w of dimethicone silicone,0.1% to 0.2% w/w of Glycacil 2000 (iodopropynyl butylcarbamate), and1.0% to 3.0% w/w of palmitoyl tetrapeptide-7. In some embodiments, thecompositions may comprise 0.01% to 0.1% w/w of Opuntia tuna fruitextract. Also contemplated is a method of reducing the appearance ofdark circles or puffiness in the periorbital region of a person's facecomprising topically applying the compositions to skin in need thereof,wherein topical application reduces the appearance of dark circles orpuffiness in the periorbital region of a person's face.

In a further aspect, there is a disclosed a cleanser comprising any oneof, a combination of, or all of water, glycerin, triethanolamine,phenoxyethanol, disodium EDTA, hydroxypropyl cyclodextrin, iodopropynylbutylcarbamate, tea-lauryl sulfate, cocamidopropyl betaine, propyleneglycol, sodium methyl cocoyl taurate, dimethicone, lauramine oxide,acrylates/C10-30 alkyl acrylate crosspolymer, sodium chloride, caprylylglycol, C12-15 alkyl benzoate, benzyl alcohol, PEG-150 distearate,PPG-26-buteth-26, and PEG-40 hydrogenated castor oil. Further,additional ingredients can be added to obtain a desired tactile propertyand/or to obtain a particular skin benefit. The amounts of theingredients within the composition can vary (e.g., amounts can be as lowas 0.000001% to as high as 95% w/w or any range therein). In oneinstance, the composition includes 25% to 95% w/w of water, 1% to 10%w/w glycerin, 0.1% to 2% w/w triethanolamine, 0.1% to 2% w/wphenoxyethanol, 0.01% to 0.2% w/w disodium EDTA, 0.01% to 0.2% w/whydroxypropyl cyclodextrin, 0.001% to 0.02% w/w iodopropynylbutylcarbamate, 5% to 10% w/w tea-lauryl sulfate, 1% to 3% w/wcocamidopropyl betaine, 1% to 3% w/w propylene glycol, 1% to 3% w/wsodium methyl cocoyl taurate, 1% to 3% w/w dimethicone, 0.1% to 3% w/wlauramine oxide, 0.1% to 3% w/w acrylates/C10-30 alkyl acrylatecrosspolymer, 0.1% to 1% w/w sodium chloride, 0.1% to 1% w/w caprylylglycol, 0.1% to 1% w/w C12-15 alkyl benzoate, 0.1% to 1% w/w benzylalcohol, 0.1% to 1% w/w PEG-150 distearate, 0.1% to 1% w/wPPG-26-buteth-26, and 0.1% to 1% w/w PEG-40 hydrogenated castor oil.

Also, herein there is disclosed an aqueous gel that is capable ofmoisturizing skin. The aqueous gel can be a serum. The formulation caninclude one, a combination of, or all of water, glycerin,triethanolamine, phenoxyethanol, disodium EDTA, hydroxypropylcyclodextrin, iodopropynyl butylcarbamate, butylene glycol, niacinamide,hydroxypropyl cyclodextrin, adenosine, acetyl dipeptide-1 cetyl ester,palmitoyl oligopeptide, palmitoyl tetrapeptide-7, acrylates/vinylisodecanoate crosspolymer, and hydroxyethylcellulose. Further,additional ingredients can be added to obtain a desired tactile propertyand/or to obtain a particular skin benefit. The amounts of theingredients within the composition can vary (e.g., amounts can be as lowas 0.000001% to as high as 95% w/w or any range therein). In oneinstance, the composition includes 25% to 95% w/w of water, 1% to 10%w/w glycerin, 0.1% to 2% w/w triethanolamine, 0.1% to 2% w/wphenoxyethanol, 0.01% to 0.2% w/w disodium EDTA, 0.01% to 0.2% w/whydroxypropyl cyclodextrin, 0.001% to 0.02% w/w iodopropynylbutylcarbamate, 5% to 10% w/w butylene glycol, 1% to 3% w/w niacinamide,0.01% to 0.3% w/w hydroxypropyl cyclodextrin, 0.01% to 0.3% w/wadenosine, 0.001% to 0.1% w/w acetyl dipeptide-1 cetyl ester, 0.00001%to 0.001% w/w palmitoyl oligopeptide, 0.00001% to 0.001% w/w palmitoyltetrapeptide-7, 0.1% to 3% w/w acrylates/vinyl isodecanoatecrosspolymer, and 0.1% to 3% w/w hydroxyethylcellulose.

In yet another aspect of the invention there is disclosed a combinationof ingredients that can work to simultaneously treat fine lines andwrinkles, inhibit or reduce skin pigmentation, and treat inflamed orerythemic skin. The combination of ingreidnets includes niacinamide,acetyl dipeptide-1 cetyl ester, palmitoyl oligopeptide, and palmitoyltetrapeptide-7. The niacinamide can inhibit skin pigmentation. Both ofpalmitoyl oligopeptide and palmitoyl tetrapeptide-7 can increase theproduction of colleagen in skin, thereby filling in fine lines andwrinkles. Acetyl dipeptide-1 cetyl ester can treat inflamed or erythemicskin by inbiting TNF-α and Il-1-α in skin. This combination ofingredients can be used in any of the compositions disclosed throughoutthe specification (e.g., moisturizes, cleansers, eye creams, or aqueousgels), thereby providing the aforementioned attributes to thecompositions. In a particularly preferred embodiment, the combination ofingredients is used in the aqueous gel composition disclosed throughoutthe specification. The amounts of the ingredients to be included in acomposition of the present invention can be modified as desired toachieve a particular result. In a preferred embodiment, the amounts caninclude 1% to 3% w/w niacinamide, 0.001% to 0.1% w/w acetyl dipeptide-1cetyl ester, 0.00001% to 0.001% w/w palmitoyl oligopeptide, and 0.00001%to 0.001% w/w palmitoyl tetrapeptide-7.

The compositions of the present invention can also include any one of,any combination of, or all of the following additional ingredients:water, a chelating agent, a moisturizing agent, a preservative, athickening agent, a silicone containing compound, an essential oil, astructuring agent, a vitamin, a pharmaceutical ingredient, or anantioxidant, or any combination of such ingredients or mixtures of suchingredients. In certain aspects, the composition can include at leasttwo, three, four, five, six, seven, eight, nine, ten, or all of theseadditional ingredients identified in the previous sentence. Non-limitingexamples of these additional ingredients are identified throughout thisspecification and are incorporated into this section by reference. Theamounts of such ingredients can range from 0.0001% to 99.9% by weight orvolume of the composition, or any integer or range in between asdisclosed in other sections of this specification, which areincorporated into this paragraph by reference.

Also disclosed in the context of the present invention are embodiments 1to 40. Embodiment 1 is a topical skin composition comprising: water;glycerin; butylene glycol; ethylene/acrylic acid copolymer;Butyrospermum parkii butter; disodium EDTA; and triethanolamine.Embodiment 2 is the topical skin composition of embodiment 1, comprising25% to 70% w/w of water; 1% to 10% w/w of glycerin; 0.5% to 6% w/w ofbutylene glycol; 0.5% to 3% w/w of ethylene/acrylic acid copolymer; 0.5%to 5% w/w of Butyrospermum parkii butter; 0.01% to 0.2% w/w of disodiumEDTA; and 0.05% to 1% w/w of triethanolamine. Embodiment 3 is thetopical skin composition of any of embodiments 1-2, wherein it iscapable of moisturizing skin. Embodiment 4 is the topical skincomposition of any of embodiments 1-3, wherein the composition isformulated as a cream and has a sun protection factor of around 30.Embodiment 5 is the topical skin composition of any of embodiments 1-4,further comprising: oxybenzone; octisalate; octocrylene; homosalate;avobenzone; and styrene/acrylates copolymer. Embodiment 6 is the topicalskin composition of embodiment 5, comprising 3.0% to 5.0% w/w ofoxybenzone; 4.0% to 5.0% w/w of octisalate; 2.0% to 3.0% w/w ofoctocrylene; 5.0% to 7.0% w/w of homosalate; 1.0% to 3.0% w/w ofavobenzone; and 1.0% to 7.0% w/w of styrene/acrylates copolymer.Embodiment 7 is the topical skin composition of any of embodiments 5-6,further comprising: glycereth-26; allantoin; xanthan gum; panthenol;tocopheryl acetate; sodium PCA; benzyl alcohol; PEG-100 stearate;lauramine oxide; C9-15 alkyl phosphate; polymethylsilsesquioxane; methyltrimethicone; and acrylates/dimethicone copolymer. Embodiment 8 is thetopical skin composition of any of embodiments 5-6, further comprising:trisiloxane; cetearyl alcohol; C12-15 alkyl benzoate; phenethylbenzoate; polyester-7; ceteth-20 phosphate; neopentyl glycoldiheptanoate; dimethicone; dipropylene glycol dibenzoate; dicetylphosphate; caprylyl glycol; methyl trimethicone; methyldihydrojasmonate;hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer;pentylene glycol; squalane; ethylene brassylate; ethyl linalool; PPG-15stearyl ether benzoate; sorbic acid; polysorbate 60; isobutyl methyltetrahydropyranol; trimethylbenzenepropanol; sorbitan isostearate;phenylisohexanol; and ammonium hydroxide. Embodiment 9 is the topicalskin composition of any of embodiments 5-6, further comprising:trisiloxane; C12-15 alkyl benzoate; phenethyl benzoate; polyester-7;neopentyl glycol diheptanoate; glyceryl stearate; hydroxyethylacrylate/sodium acryloyldimethyl taurate copolymer; dipropylene glycoldibenzoate; arachidyl alcohol; caprylyl glycol; squalane;methyldihydrojasmonate; potassium cetyl phosphate; dimethicone;steareth-21; hydrogenated palm glycerides; pentylene glycol; behenylalcohol; arachidyl glucoside; ethylene brassylate; PPG-15 stearyl etherbenzoate; ethyl linalool; polysorbate 60; hydrogenated lecithin; sorbicacid; isobutyl methyl tetrahydropyranol; trimethylbenzenepropanol;sorbitan isostearate; phenylisohexanol; and ammonium hydroxide.Embodiment 10 is the topical skin composition of any of embodiments 5-6,further comprising: trisiloxane; C12-15 alkyl benzoate; phenethylbenzoate; polyester-7; neopentyl glycol diheptanoate; glyceryl stearate;hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer;dipropylene glycol dibenzoate; arachidyl alcohol; caprylyl glycol;squalane; methyldihydrojasmonate; potassium cetyl phosphate;dimethicone; hydrogenated palm glycerides; pentylene glycol; behenylalcohol; arachidyl glucoside; ethylene brassylate; ethyl linalool;PPG-15 stearyl ether benzoate; polysorbate 60; hydrogenated lecithin;sorbic acid; isobutyl methyl tetrahydropyranol;trimethylbenzenepropanol; sorbitan isostearate; phenylisohexanol; andammonium hydroxide. Embodiment 11 is the topical skin composition of anyof embodiments 5-6, further comprising: C12-15 alkyl benzoate;trisiloxane; polyester-7; neopentyl glycol diheptanoate; glycerylstearate; benzyl alcohol; hydroxyethyl acrylate/sodium acryloydimethyltaurate copolymer; arachidyl alcohol; caprylyl glycol; squalane;methyldihydrojasmonate; potassium cetyl phosphate; dimethicone;hydrogenated palm glycerides; pentylene glycol; behenyl alcohol;arachidyl glucoside; ethylene brassylate; ethyl linalool; polysorbate60; C9-15 alkyl phosphate; tocopheryl acetate; hydrogenated lecithin;sorbic acid; isobutyl methyl tetrahydropyranol;trimethylbenzenepropanol; sorbitan isostearate; phenylisohexanol; andammonium hydroxide. Embodiment 12 is the topical skin composition of anyof embodiments 5-6, further comprising: trisiloxane; C12-15 alkylbenzoate; phenethyl benzoate; polyester-7; neopentyl glycoldiheptanoate; glyceryl stearate; dimethicone; hydroxyethylacrylate/sodium acryloydimethyl taurate copolymer; phenoxyethanol;dipropylene glycol dibenzoate; ceteryl alcohol; caprylyl glycol;squalane; methyldihydrojasmonate; ceteth-20 phosphate; pentylene glycol;dicetyl phosphate; ethylene brassylate; ethyl linalool; PPG-15 stearylether benzoate; polysorbate 60; sorbic acid; isobutyl methyltetrahydropyranol; trimethylbenzenepropanol; sorbitan isostearate;phenylisohexanol; and ammonium hydroxide. Embodiment 13 is the topicalskin composition of embodiment 7, further comprising: trisiloxane;C12-15 alkyl benzoate; butyloctyl salicylate; glyceryl stearate;trimethypentanediol/adipic acid/glycerin crosspolymer; hydroxyethylacrylate/sodium acryloyldimethyl taurate copolymer; dipropylene glycoldibenzoate; arachidyl alcohol; caprylyl glycol; squalane;methyldihydrojasmonate; potassium cetyl phosphate; dimethicone;steareth-21; hydrogenated palm glycerides; pentylene glycol; behenylalcohol; arachidyl glucoside; ethylene brassylate; ethyl linalool;PPG-15 stearyl ether benzoate; polysorbate 60; hydrogenated lecithin;sorbic acid; isobutyl methyl tetrahydropryranol;trimethylbenzenepropanol; adenosine; sorbitan isostearate;phenylisohexanol; ammonium hydroxide; and sodium benzoate. Embodiment 14is the topical skin composition of embodiment 13, further comprisingOpuntia tuna fruit extract. Embodiment 15 is the topical skincomposition of embodiment 14, comprising 0.0001% to 0.1% w/w of Opuntiatuna fruit extract. Embodiment 16 is a method of protecting skin from UVradiation comprising topically applying any one of the compositions ofembodiments 1-15 to skin in need thereof, wherein topical application ofsaid compositions protects the skin from UV radiation. Embodiment 17 isthe topical skin composition of any of embodiments 1-2, wherein it iscapable of treating the skin around the eyes. Embodiment 18 is thetopical skin composition of any of embodiments 1, 2, or 17, wherein thecomposition is formulated as a cream capable of reducing the appearanceof dark circles or puffy eyes. Embodiment 19 is the topical skincomposition of embodiment 1, further comprising: phenoxyethanol;Carbopol Ultrez 10 (carbomer); cetearyl glucoside; chlorphenesin;adenosine; betaine; Hispagel 200 NS (glycerin and glycerylpolyacrylate); cetearyl alcohol; ceteareth-20; C12-15 alcohols benzoate;hydrogenated polydecene; polyethylene; cetyl esters; behenyl alcohol;eldew PS-304 (phytosteryl/behenyl/octyldodecyl lauroyl glutamate);dipalmit hydroxyproline; dimethicone silicone; Glycacil 2000(iodopropynyl butylcarbamate); and palmitoyl tetrapeptide-7. Embodiment20 is the topical skin composition of any one of embodiments 1-2,comprising 0.5% to 1.5% w/w of phenoxyethanol; 0.2% to 0.4% w/w ofCarbopol Ultrez 10 (carbomer); 0.5% to 1.5% w/w of cetearyl glucoside;0.2% to 0.3% w/w of chlorphenesin; 0.01% to 0.1% w/w of adenosine; 1.0%to 5.0% w/w of betaine; 2.0% to 3.0% w/w of Hispagel 200 NS (glycerinand glyceryl polyacrylate); 0.25% to 1.5% w/w of cetearyl alcohol; 0.25%to 1.5% w/w of ceteareth-20; 2.0% to 4.0% w/w of C12-15 alcoholsbenzoate; 2.0% to 3.0% w/w of hydrogenated polydecene; 2.0% to 3.0% w/wof polyethylene; 1.0% to 1.5% w/w of cetyl esters; 1.0% to 1.5% w/w ofbehenyl alcohol; 0.25% to 1.0% w/w of eldew PS-304(phytosteryl/behenyl/octyldodecyl lauroyl glutamate); 0.25% to 1.0% w/wof dipalmit hydroxyproline; 0.5% to 1.5% w/w of dimethicone silicone;0.1% to 0.2% w/w of Glycacil 2000 (iodopropynyl butylcarbamate); and1.0% to 3.0% w/w of palmitoyl tetrapeptide-7. Embodiment 21 is thetopical skin composition of embodiment 19, further comprising Opuntiatuna fruit extract. Embodiment 22 is the topical skin composition ofembodiment 21, comprising 0.01% to 0.1% w/w of Opuntia tuna fruitextract. Embodiment 23 is a method of reducing the appearance of darkcircles or puffiness in the periorbital region of a person's facecomprising topically applying any one of the compositions of embodiments1, 2, or 18-22 to skin in need thereof, wherein topical applicationreduces the appearance of dark circles or puffiness in the periorbitalregion of a person's face. Embodiment 24 is a topical skin compositioncomprising: water; glycerin; triethanolamine; phenoxyethanol; disodiumEDTA; hydroxypropyl cyclodextrin; and iodopropynyl butylcarbamate.Embodiment 25 is the topical skin composition of embodiment 24,comprising 70% to 95% w/w of water; 1% to 10% w/w glycerin; 0.1% to 2%w/w triethanolamine; 0.1% to 2% w/w phenoxyethanol; 0.01% to 0.2% w/wdisodium EDTA; 0.01% to 0.2% w/w hydroxypropyl cyclodextrin; and 0.001%to 0.02% w/w iodopropynyl butylcarbamate. Embodiment 26 is the topicalskin composition of embodiment 25, wherein the composition is a skincleanser. Embodiment 27 is the topical skin composition of embodiment 26further comprising: tea-lauryl sulfate; cocamidopropyl betaine;propylene glycol; sodium methyl cocoyl taurate; dimethicone; lauramineoxide; and acrylates/C10-30 alkyl acrylate crosspolymer. Embodiment 28is the topical skin composition of embodiment 27, comprising 5% to 10%w/w tea-lauryl sulfate; 1% to 3% w/w cocamidopropyl betaine; 1% to 3%w/w propylene glycol; 1% to 3% w/w sodium methyl cocoyl taurate; 1% to3% w/w dimethicone; 0.1% to 3% w/w lauramine oxide; and 0.1% to 3% w/wacrylates/C10-30 alkyl acrylate crosspolymer. Embodiment 29 is thetopical skin composition of embodiment 28 further comprising: sodiumchloride; caprylyl glycol; C12-15 alkyl benzoate; benzyl alcohol;PEG-150 distearate; PPG-26-buteth-26; and PEG-40 hydrogenated castoroil. Embodiment 30 is the topical skin composition of embodiment 29,comprising 0.1% to 1% w/w sodium chloride; 0.1% to 1% w/w caprylylglycol; 0.1% to 1% w/w C12-15 alkyl benzoate; 0.1% to 1% w/w benzylalcohol; 0.1% to 1% w/w PEG-150 distearate; 0.1% to 1% w/wPPG-26-buteth-26; and 0.1% to 1% w/w PEG-40 hydrogenated castor oil.Embodiment 31 is the topical skin composition of embodiment 25, whereinthe composition is an aqueous gel that is capable of moisturizing skin,treating fine lines and wrinkles, reducing skin pigmentation, ortreating erythemic or inflamed skin. Embodiment 32 is the topical skincomposition of embodiment 31, further comprising: niacinamide; acetyldipeptide-1 cetyl ester; palmitoyl oligopeptide; and palmitoyltetrapeptide-7. Embodiment 33 is the topical skin composition ofembodiment 32, comprising: 1% to 3% w/w niacinamide; 0.001% to 0.1% w/wacetyl dipeptide-1 cetyl ester; 0.00001% to 0.001% w/w palmitoyloligopeptide; and 0.00001% to 0.001% w/w palmitoyl tetrapeptide-7.Embodiment 34 is the topical skin composition of embodiment 33 furthercomprising: butylene glycol; hydroxypropyl cyclodextrin; and adenosine.Embodiment 35 is the topical skin composition of embodiment 34,comprising: 5% to 10% w/w butylene glycol; 0.01% to 0.3% w/whydroxypropyl cyclodextrin; and 0.01% to 0.3% w/w adenosine. Embodiment36 is the topical skin composition of embodiment 35 further comprising:acrylates/vinyl isodecanoate crosspolymer; and hydroxyethylcellulose.Embodiment 37 is the topical skin composition of embodiment 36,comprising 0.1% to 3% w/w acrylates/vinyl isodecanoate crosspolymer; and0.1% to 3% w/w hydroxyethylcellulose. Embodiment 38 is a method ofcleansing skin comprising applying to skin a composition of any ofembodiments 24-30. Embodiment 39 is a method of moisturizing skin,treating fine lines and wrinkles, reducing skin pigmentation, ortreating erythemic or inflamed skin comprising applying to skin in needthereof any one of the compositions of embodiments 31 to 37. Embodiment40 is the method of embodiment 39 wherein the composition is applied tofacial skin.

Kits that include the compositions of the present invention are alsocontemplated. In certain embodiments, the composition is comprised in acontainer. The container can be a bottle, dispenser, or package. Thecontainer can dispense a pre-determined amount of the composition. Incertain aspects, the compositions is dispensed in a spray, dollop, orliquid. The container can include indicia on its surface. The indiciacan be a word, an abbreviation, a picture, or a symbol.

It is also contemplated that the compositions disclosed throughout thisspecification can be used as a leave-on or rinse-off composition. By wayof example, a leave-on composition can be one that is topically appliedto skin and remains on the skin for a period of time (e.g., at least 5,6, 7, 8, 9, 10, 20, or 30 minutes, or at least 1, 2, 3, 4, 5, 6, 7, 8,9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 or 24 hours,or over night or throughout the day). Alternatively, a rinse-offcomposition can be a product that is intended to be applied to the skinand then removed or rinsed from the skin (e.g., with water) within aperiod of time such as less than 5, 4, 3, 2, or 1 minute. An example ofa rinse of composition can be a skin cleanser, shampoo, conditioner, orsoap. An example of a leave-on composition can be a skin moisturizer,sunscreen, mask, overnight cream, or a day cream.

It is contemplated that any embodiment discussed in this specificationcan be implemented with respect to any method or composition of theinvention, and vice versa. Furthermore, compositions of the inventioncan be used to achieve methods of the invention.

In one embodiment, compositions of the present invention can bepharmaceutically or cosmetically elegant or can have pleasant tactileproperties. “Pharmaceutically elegant,” “cosmetically elegant,” and/or“pleasant tactile properties” describes a composition that hasparticular tactile properties which feel pleasant on the skin (e.g.,compositions that are not too watery or greasy, compositions that have asilky texture, compositions that are non-tacky or sticky, etc.).Pharmaceutically or cosmetically elegant can also relate to thecreaminess or lubricity properties of the composition or to the moistureretaining properties of the composition.

“Topical application” means to apply or spread a composition onto thesurface of lips or keratinous tissue. “Topical skin composition”includes compositions suitable for topical application on lips orkeratinous tissue. Such compositions are typicallydermatologically-acceptable in that they do not have undue toxicity,incompatibility, instability, allergic response, and the like, whenapplied to lips or skin. Topical skin care compositions of the presentinvention can have a selected viscosity to avoid significant dripping orpooling after application to skin.

“Keratinous tissue” includes keratin-containing layers disposed as theoutermost protective covering of mammals and includes, but is notlimited to, lips, skin, hair and nails.

The term “about” or “approximately” are defined as being close to asunderstood by one of ordinary skill in the art, and in one non-limitingembodiment the terms are defined to be within 10%, preferably within 5%,more preferably within 1%, and most preferably within 0.5%.

The term “substantially” and its variations are defined as being largelybut not necessarily wholly what is specified as understood by one ofordinary skill in the art, and in one non-limiting embodimentsubstantially refers to ranges within 10%, within 5%, within 1%, orwithin 0.5%.

The terms “inhibiting” or “reducing” or any variation of these termsincludes any measurable decrease or complete inhibition to achieve adesired result. The terms “promote” or “increase” or any variation ofthese terms includes any measurable increase or production of a proteinor molecule (e.g., matrix proteins such as fibronectin, laminin,collagen, or elastin or molecules such as hyaluronic acid) to achieve adesired result.

The term “effective,” as that term is used in the specification and/orclaims, means adequate to accomplish a desired, expected, or intendedresult.

The use of the word “a” or “an” when used in conjunction with the term“comprising” in the claims and/or the specification may mean “one,” butit is also consistent with the meaning of “one or more,” “at least one,”and “one or more than one.”

As used in this specification and claim(s), the words “comprising” (andany form of comprising, such as “comprise” and “comprises”), “having”(and any form of having, such as “have” and “has”), “including” (and anyform of including, such as “includes” and “include”) or “containing”(and any form of containing, such as “contains” and “contain”) areinclusive or open-ended and do not exclude additional, unrecitedelements or method steps.

The compositions and methods for their use can “comprise,” “consistessentially of,” or “consist of” any of the ingredients or stepsdisclosed throughout the specification. With respect to the transitionalphase “consisting essentially of,” in one non-limiting aspect, a basicand novel characteristic of the compositions and methods disclosed inthis specification includes the compositions' abilities to moisturizeskin, reduce the appearance of fine lines and wrinkles, inhibit skinpigmentation, and/or treat inflamed or erythemic skin.

Other objects, features and advantages of the present invention willbecome apparent from the following detailed description. It should beunderstood, however, that the detailed description and the examples,while indicating specific embodiments of the invention, are given by wayof illustration only. Additionally, it is contemplated that changes andmodifications within the spirit and scope of the invention will becomeapparent to those skilled in the art from this detailed description.

DESCRIPTION OF ILLUSTRATIVE EMBODIMENTS

Given the number of various products on the market today, a person isoftentimes at a loss to identify an appropriate product. In addition,the skin of men has different needs from the skin of women and, whilewomen have a large selection of skincare products to choose from, theoptions available formulated specifically for men are much fewer. Thisleaves them with the choice of having to identify one of a large numberof female-designed products or of selecting from a narrower range ofproducts designed for male skin. With this backdrop in mind, theinventors discovered various formulations that can be used to treat andprotect skin, and in particular men's skin. These formulations can beused individually or in a regimen-based format.

The cosmetic moisturizers of the present invention can be used tomoisturize, maintain, and improve the health of skin. For instance, themoisturizers can provide many advantages including: moisturizing skin;maintaining skin hydration; nourishing skin; controlling excess sebum oroil build-up; leaving the skin feeling non-greasy or non-oily;protecting the skin from damaging rays of the sun. They are typicallyformulated as oil-in-water emulsions.

One cream of the present invention is designed to be used during the daydue, in part, to its sun protection factor (SPF) 30 protection for skin.It can include one, a combination of, or all of oxybenzone, octisalate,octocrylene, homosalate, avobenzone, styrene/acrylates copolymer, water,glycerin, butylene glycol, ethylene/acrylic acid copolymer,Butyrospermum parkii butter, disodium EDTA, triethanolamine,glycereth-26, allantoin, xantham gum, panthenol, tocopherol acetate,sodium PCA, benzyl alcohol, PEG-100 stearate, lauramine oxide, C9-15alkyl phosphate, polymethylsilsesquioxane, methyl trimethicone,acrylates/dimethicone copolymer, trisiloxane, cetearyl alcohol, C12-15alkyl benzoate, phenethyl benzoate, polyester-7, ceteth-20 phosphate,neopentyl glycol diheptanoate, dimethicone, dipropylene glycoldibenzoate, dicetyl phosphate, caprylyl glycol, methyl trimethicone,methyldihydrojasmonate, hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer, pentylene glycol, squalane, ethylene brassylate,ethyl linalool, PPG-15 stearyl ether benzoate, sorbic acid, polysorbate60, isobutyl methyl tetrahydropyranol, trimethylbenzenepropanol,sorbitan isostearate, phenylisohexanol, ammonium hydroxide, glycerylstearate, arachidyl alcohol, potassium cetyl phosphate, steareth-21,hydrogenated palm glycerides, behenyl alcohol, arachidyl glucoside,hydrogenated lecithin, benzyl alcohol, hydroxyethyl acrylate/sodiumacryloydimethyl taurate copolymer, C9-15 alkyl phosphate, tocopherylacetate, phenoxyethanol, ceteryl alcohol, trimethypentanediol/adipicacid/glycerin crosspolymer, isobutyl methyl tetrahydropryranol,adenosine, sodium benzoate, and Opuntia tuna fruit extract. Further,additional ingredients can be added to obtain a desired tactile propertyand/or to obtain a particular skin benefit.

In a further instance, there is disclosed a cream that is designed forskin around the eyes (periorbital region). The cream can be designed insuch a manner so as to account for the thinner and more sensitive skinin the periorbital region of a person's face. The formulation mayminimize the appearance of under-eye bags and dark circles. Theformulation can include one of, any combination of, or all of water,glycerin, butylene glycol, ethylene/acrylic acid copolymer,Butyrospermum parkii butter, disodium EDTA, triethanolamine,phenoxyethanol, Carbopol Ultrez 10 (carbomer), cetearyl glucoside,chlorphenesin, adenosine, betaine, Hispagel 200 NS (glycerin andglyceryl polyacrylate), cetearyl alcohol, ceteareth-20, C12-15 alcoholsbenzoate, hydrogenated polydecene, polyethylene, cetyl esters, behenylalcohol, eldew PS-304 (phytosteryl/behenyl/octyldodecyl lauroylglutamate), dipalmit hydroxyproline, dimethicone silicone, Glycacil 2000(iodopropynyl butylcarbamate), palmitoyl tetrapeptide-7, and Opuntiatuna fruit extract. Further, additional ingredients can be added toobtain a desired tactile property and/or to obtain a particular skinbenefit.

In another instance, there is a disclosed a cleanser. The formulationcan include one, a combination of, or all of water, glycerin,triethanolamine, phenoxyethanol, disodium EDTA, hydroxypropylcyclodextrin, iodopropynyl butylcarbamate, tea-lauryl sulfate,cocamidopropyl betaine, propylene glycol, sodium methyl cocoyl taurate,dimethicone, lauramine oxide, acrylates/C10-30 alkyl acrylatecrosspolymer, sodium chloride, caprylyl glycol, C12-15 alkyl benzoate,benzyl alcohol, PEG-150 distearate, PPG-26-buteth-26, and PEG-40hydrogenated castor oil. Further, additional ingredients can be added toobtain a desired tactile property and/or to obtain a particular skinbenefit.

Also, herein there is disclosed an aqueous gel that is capable ofmoisturizing skin. The formulation can include one, a combination of, orall of water, glycerin, triethanolamine, phenoxyethanol, disodium EDTA,hydroxypropyl cyclodextrin, iodopropynyl butylcarbamate, butyleneglycol, niacinamide, hydroxypropyl cyclodextrin, adenosine, acetyldipeptide-1 cetyl ester, palmitoyl oligopeptide, palmitoyltetrapeptide-7, acrylates/vinyl isodecanoate crosspolymer, andhydroxyethylcellulose. Further, additional ingredients can be added toobtain a desired tactile property and/or to obtain a particular skinbenefit.

A. Amounts of Ingredients

It is contemplated that the compositions of the present invention caninclude any amount of the ingredients discussed in this specification.The compositions can also include any number of combinations ofadditional ingredients described throughout this specification (e.g.,pigments, or additional cosmetic or pharmaceutical ingredients). Theconcentrations of the any ingredient within the compositions can vary.In non-limiting embodiments, for example, the compositions can comprise,consisting essentially of, or consist of, in their final form, forexample, at least about 0.0001%, 0.0002%, 0.0003%, 0.0004%, 0.0005%,0.0006%, 0.0007%, 0.0008%, 0.0009%, 0.0010%, 0.0011%, 0.0012%, 0.0013%,0.0014%, 0.0015%, 0.0016%, 0.0017%, 0.0018%, 0.0019%, 0.0020%, 0.0021%,0.0022%, 0.0023%, 0.0024%, 0.0025%, 0.0026%, 0.0027%, 0.0028%, 0.0029%,0.0030%, 0.0031%, 0.0032%, 0.0033%, 0.0034%, 0.0035%, 0.0036%, 0.0037%,0.0038%, 0.0039%, 0.0040%, 0.0041%, 0.0042%, 0.0043%, 0.0044%, 0.0045%,0.0046%, 0.0047%, 0.0048%, 0.0049%, 0.0050%, 0.0051%, 0.0052%, 0.0053%,0.0054%, 0.0055%, 0.0056%, 0.0057%, 0.0058%, 0.0059%, 0.0060%, 0.0061%,0.0062%, 0.0063%, 0.0064%, 0.0065%, 0.0066%, 0.0067%, 0.0068%, 0.0069%,0.0070%, 0.0071%, 0.0072%, 0.0073%, 0.0074%, 0.0075%, 0.0076%, 0.0077%,0.0078%, 0.0079%, 0.0080%, 0.0081%, 0.0082%, 0.0083%, 0.0084%, 0.0085%,0.0086%, 0.0087%, 0.0088%, 0.0089%, 0.0090%, 0.0091%, 0.0092%, 0.0093%,0.0094%, 0.0095%, 0.0096%, 0.0097%, 0.0098%, 0.0099%, 0.0100%, 0.0200%,0.0250%, 0.0275%, 0.0300%, 0.0325%, 0.0350%, 0.0375%, 0.0400%, 0.0425%,0.0450%, 0.0475%, 0.0500%, 0.0525%, 0.0550%, 0.0575%, 0.0600%, 0.0625%,0.0650%, 0.0675%, 0.0700%, 0.0725%, 0.0750%, 0.0775%, 0.0800%, 0.0825%,0.0850%, 0.0875%, 0.0900%, 0.0925%, 0.0950%, 0.0975%, 0.1000%, 0.1250%,0.1500%, 0.1750%, 0.2000%, 0.2250%, 0.2500%, 0.2750%, 0.3000%, 0.3250%,0.3500%, 0.3750%, 0.4000%, 0.4250%, 0.4500%, 0.4750%, 0.5000%, 0.5250%,0.0550%, 0.5750%, 0.6000%, 0.6250%, 0.6500%, 0.6750%, 0.7000%, 0.7250%,0.7500%, 0.7750%, 0.8000%, 0.8250%, 0.8500%, 0.8750%, 0.9000%, 0.9250%,0.9500%, 0.9750%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%,1.9%, 2.0%, 2.1%, 2.2%, 2.3%, 2.4%, 2.5%, 2.6%, 2.7%, 2.8%, 2.9%, 3.0%,3.1%, 3.2%, 3.3%, 3.4%, 3.5%, 3.6%, 3.7%, 3.8%, 3.9%, 4.0%, 4.1%, 4.2%,4.3%, 4.4%, 4.5%, 4.6%, 4.7%, 4.8%, 4.9%, 5.0%, 5.1%, 5.2%, 5.3%, 5.4%,5.5%, 5.6%, 5.7%, 5.8%, 5.9%, 6.0%, 6.1%, 6.2%, 6.3%, 6.4%, 6.5%, 6.6%,6.7%, 6.8%, 6.9%, 7.0%, 7.1%, 7.2%, 7.3%, 7.4%, 7.5%, 7.6%, 7.7%, 7.8%,7.9%, 8.0%, 8.1%, 8.2%, 8.3%, 8.4%, 8.5%, 8.6%, 8.7%, 8.8%, 8.9%, 9.0%,9.1%, 9.2%, 9.3%, 9.4%, 9.5%, 9.6%, 9.7%, 9.8%, 9.9%, 10%, 11%, 12%,13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%,27%, 28%, 29%, 30%, 35%, 40%, 45%, 50%, 60%, 65%, 70%, 75%, 80%, 85%,90%, 95%, or 99% or any range derivable therein, of at least one of theingredients that are mentioned throughout the specification and claims.In non-limiting aspects, the percentage can be calculated by weight orvolume of the total composition. A person of ordinary skill in the artwould understand that the concentrations can vary depending on theaddition, substitution, and/or subtraction of ingredients in a givencomposition.

B. Vehicles

The compositions of the present invention can be incorporated into alltypes of vehicles. Non-limiting examples include emulsions (e.g.,water-in-oil, water-in-oil-in-water, oil-in-water, silicone-in-water,water-in-silicone, oil-in-water-in-oil, oil-in-water-in-siliconeemulsions), creams, lotions, solutions (both aqueous andhydro-alcoholic), anhydrous bases (such as lipsticks and powders), gels,and ointments. Variations and other appropriate vehicles will beapparent to the skilled artisan and are appropriate for use in thepresent invention. In certain aspects, it is important that theconcentrations and combinations of the compounds, ingredients, andagents be selected in such a way that the combinations are chemicallycompatible and do not form complexes which precipitate from the finishedproduct.

C. Additional Ingredients

In addition to the combination of ingredients disclosed by theinventors, the compositions can also include additional ingredients suchas cosmetic ingredients and pharmaceutical active ingredients.Non-limiting examples of these additional ingredients are described inthe following subsections.

1. Cosmetic Ingredients

The CTFA International Cosmetic Ingredient Dictionary and Handbook (2004and 2008) describes a wide variety of non-limiting cosmetic ingredientsthat can be used in the context of the present invention. Examples ofthese ingredient classes include: fragrances (artificial and natural),dyes and color ingredients (e.g., Blue 1, Blue 1 Lake, Red 40, titaniumdioxide, D&C blue no. 4, D&C green no. 5, D&C orange no. 4, D&C red no.17, D&C red no. 33, D&C violet no. 2, D&C yellow no. 10, and D&C yellowno. 11), adsorbents, lubricants, solvents, moisturizers (including,e.g., emollients, humectants, film formers, occlusive agents, and agentsthat affect the natural moisturization mechanisms of the skin),water-repellants, UV absorbers (physical and chemical absorbers such asparaaminobenzoic acid (“PABA”) and corresponding PABA derivatives,titanium dioxide, zinc oxide, etc.), essential oils, vitamins (e.g. A,B, C, D, E, and K), trace metals (e.g. zinc, calcium and selenium),anti-irritants (e.g. steroids and non-steroidal anti-inflammatories),botanical extracts (e.g. aloe vera, chamomile, cucumber extract, ginkgobiloba, ginseng, and rosemary), anti-microbial agents, antioxidants(e.g., BHT and tocopherol), chelating agents (e.g., disodium EDTA andtetrasodium EDTA), preservatives (e.g., methylparaben andpropylparaben), pH adjusters (e.g., sodium hydroxide and citric acid),absorbents (e.g., aluminum starch octenylsuccinate, kaolin, corn starch,oat starch, cyclodextrin, talc, and zeolite), skin bleaching andlightening agents (e.g., hydroquinone and niacinamide lactate),humectants (e.g., sorbitol, urea, and manitol), exfoliants,waterproofing agents (e.g., magnesium/aluminum hydroxide stearate), skinconditioning agents (e.g., aloe extracts, allantoin, bisabolol,ceramides, dimethicone, hyaluronic acid, and dipotassium glycyrrhizate).Non-limiting examples of some of these ingredients are provided in thefollowing subsections.

a. UV Absorption Agents

UV absorption agents that can be used in combination with thecompositions of the present invention include chemical and physicalsunblocks. Non-limiting examples of chemical sunblocks that can be usedinclude para-aminobenzoic acid (PABA), PABA esters (glyceryl PABA,amyldimethyl PABA and octyldimethyl PABA), butyl PABA, ethyl PABA, ethyldihydroxypropyl PABA, benzophenones (oxybenzone, sulisobenzone,benzophenone, and benzophenone-1 through 12), cinnamates (octylmethoxycinnamate, isoamyl p-methoxycinnamate, octylmethoxy cinnamate,cinoxate, diisopropyl methyl cinnamate, DEA-methoxycinnamate, ethyldiisopropylcinnamate, glyceryl octanoate dimethoxycinnamate and ethylmethoxycinnamate), cinnamate esters, salicylates (homomethyl salicylate,benzyl salicylate, glycol salicylate, isopropylbenzyl salicylate, etc.),anthranilates, ethyl urocanate, homosalate, octisalate, dibenzoylmethanederivatives (e.g., avobenzone), octocrylene, octyl triazone, digalloytrioleate, glyceryl aminobenzoate, lawsone with dihydroxyacetone,ethylhexyl triazone, dioctyl butamido triazone, benzylidene malonatepolysiloxane, terephthalylidene dicamphor sulfonic acid, disodium phenyldibenzimidazole tetrasulfonate, diethylamino hydroxybenzoyl hexylbenzoate, bis diethylamino hydroxybenzoyl benzoate, bisbenzoxazoylphenyl ethylhexylimino triazine, drometrizole trisiloxane,methylene bis-benzotriazolyl tetramethylbutyiphenol, andbis-ethylhexyloxyphenol methoxyphenyltriazine,4-methylbenzylidenecamphor, and isopentyl 4-methoxycinnamate.Non-limiting examples of physical sunblocks include, kaolin, talc,petrolatum and metal oxides (e.g., titanium dioxide and zinc oxide).

b. Moisturizing Agents

Non-limiting examples of moisturizing agents that can be used with thecompositions of the present invention include amino acids, chondroitinsulfate, diglycerin, erythritol, fructose, glucose, glycerin, glycerolpolymers, glycol, 1,2,6-hexanetriol, honey, hyaluronic acid,hydrogenated honey, hydrogenated starch hydrolysate, inositol, lactitol,maltitol, maltose, mannitol, natural moisturizing factor, PEG-15butanediol, polyglyceryl sorbitol, salts of pyrollidone carboxylic acid,potassium PCA, propylene glycol, sodium glucuronate, sodium PCA,sorbitol, sucrose, trehalose, urea, and xylitol.

Other examples include acetylated lanolin, acetylated lanolin alcohol,alanine, algae extract, aloe barbadensis, aloe-barbadensis extract, aloebarbadensis gel, althea officinalis extract, apricot (prunus armeniaca)kernel oil, arginine, arginine aspartate, arnica montana extract,aspartic acid, avocado (persea gratissima) oil, barrier sphingolipids,butyl alcohol, beeswax, behenyl alcohol, beta-sitosterol, birch (betulaalba) bark extract, borage (borago officinalis) extract, butcherbroom(ruscus aculeatus) extract, butylene glycol, calendula officinalisextract, calendula officinalis oil, candelilla (euphorbia cerifera) wax,canola oil, caprylic/capric triglyceride, cardamon (elettariacardamomum) oil, carnauba (copernicia cerifera) wax, carrot (daucuscarota sativa) oil, castor (ricinus communis) oil, ceramides, ceresin,ceteareth-5, ceteareth-12, ceteareth-20, cetearyl octanoate, ceteth-20,ceteth-24, cetyl acetate, cetyl octanoate, cetyl palmitate, chamomile(anthemis nobilis) oil, cholesterol, cholesterol esters, cholesterylhydroxystearate, citric acid, clary (salvia sclarea) oil, cocoa(theobroma cacao) butter, coco-caprylate/caprate, coconut (cocosnucifera) oil, collagen, collagen amino acids, corn (zea mays)oil, fattyacids, decyl oleate, dimethicone copolyol, dimethiconol, dioctyladipate, dioctyl succinate, dipentaerythrityl hexacaprylate/hexacaprate,DNA, erythritol, ethoxydiglycol, ethyl linoleate, eucalyptus globulusoil, evening primrose (oenothera biennis) oil, fatty acids, geraniummaculatum oil, glucosamine, glucose glutamate, glutamic acid,glycereth-26, glycerin, glycerol, glyceryl distearate, glycerylhydroxystearate, glyceryl laurate, glyceryl linoleate, glycerylmyristate, glyceryl oleate, glyceryl stearate, glyceryl stearate SE,glycine, glycol stearate, glycol stearate SE, glycosaminoglycans, grape(vitis vinifera) seed oil, hazel (corylus americana) nut oil, hazel(corylus avellana) nut oil, hexylene glycol, hyaluronic acid, hybridsafflower (carthamus tinctorius) oil, hydrogenated castor oil,hydrogenated coco-glycerides, hydrogenated coconut oil, hydrogenatedlanolin, hydrogenated lecithin, hydrogenated palm glyceride,hydrogenated palm kernel oil, hydrogenated soybean oil, hydrogenatedtallow glyceride, hydrogenated vegetable oil, hydrolyzed collagen,hydrolyzed elastin, hydrolyzed glycosaminoglycans, hydrolyzed keratin,hydrolyzed soy protein, hydroxylated lanolin, hydroxyproline, isocetylstearate, isocetyl stearoyl stearate, isodecyl oleate, isopropylisostearate, isopropyl lanolate, isopropyl myristate, isopropylpalmitate, isopropyl stearate, isostearamide DEA, isostearic acid,isostearyl lactate, isostearyl neopentanoate, jasmine (jasminumofficinale) oil, jojoba (buxus chinensis) oil, kelp, kukui (aleuritesmoluccana) nut oil, lactamide MEA, laneth-16, laneth-10 acetate,lanolin, lanolin acid, lanolin alcohol, lanolin oil, lanolin wax,lavender (lavandula angustifolia) oil, lecithin, lemon (citrus medicalimonum) oil, linoleic acid, linolenic acid, macadamia ternifolia nutoil, maltitol, matricaria (chamomilla recutita) oil, methyl glucosesesquistearate, methylsilanol PCA, mineral oil, mink oil, mortierellaoil, myristyl lactate, myristyl myristate, myristyl propionate,neopentyl glycol dicaprylate/dicaprate, octyldodecanol, octyldodecylmyristate, octyldodecyl stearoyl stearate, octyl hydroxystearate, octylpalmitate, octyl salicylate, octyl stearate, oleic acid, olive (oleaeuropaea) oil, orange (citrus aurantium dulcis) oil, palm (elaeisguineensis) oil, palmitic acid, pantethine, panthenol, panthenyl ethylether, paraffin, PCA, peach (prunus persica) kernel oil, peanut (arachishypogaea) oil, PEG-8 C12-18 ester, PEG-15 cocamine, PEG-150 distearate,PEG-60 glyceryl isostearate, PEG-5 glyceryl stearate, PEG-30 glycerylstearate, PEG-7 hydrogenated castor oil, PEG-40 hydrogenated castor oil,PEG-60 hydrogenated castor oil, PEG-20 methyl glucose sesquistearate,PEG40 sorbitan peroleate, PEG-5 soy sterol, PEG-10 soy sterol, PEG-2stearate, PEG-8 stearate, PEG-20 stearate, PEG-32 stearate, PEG40stearate, PEG-50 stearate, PEG-100 stearate, PEG-150 stearate,pentadecalactone, peppermint (mentha piperita) oil, petrolatum,phospholipids, polyamino sugar condensate, polyglyceryl-3 diisostearate,polyquaternium-24, polysorbate 20, polysorbate 40, polysorbate 60,polysorbate 80, polysorbate 85, potassium myristate, potassiumpalmitate, propylene glycol, propylene glycol dicaprylate/dicaprate,propylene glycol dioctanoate, propylene glycol dipelargonate, propyleneglycol laurate, propylene glycol stearate, propylene glycol stearate SE,PVP, pyridoxine dipalmitate, retinol, retinyl palmitate, rice (oryzasativa) bran oil, RNA, rosemary (rosmarinus officinalis) oil, rose oil,safflower (carthamus tinctorius) oil, sage (salvia officinalis) oil,sandalwood (santalum album) oil, serine, serum protein, sesame (sesamumindicum) oil, shea butter (butyrospermum parkii), silk powder, sodiumchondroitin sulfate, sodium hyaluronate, sodium lactate, sodiumpalmitate, sodium PCA, sodium polyglutamate, soluble collagen, sorbitanlaurate, sorbitan oleate, sorbitan palmitate, sorbitan sesquioleate,sorbitan stearate, sorbitol, soybean (glycine soja) oil, sphingolipids,squalane, squalene, stearamide MEA-stearate, stearic acid, stearoxydimethicone, stearoxytrimethylsilane, stearyl alcohol, stearylglycyrrhetinate, stearyl heptanoate, stearyl stearate, sunflower(helianthus annuus) seed oil, sweet almond (prunus amygdalus dulcis)oil, synthetic beeswax, tocopherol, tocopheryl acetate, tocopheryllinoleate, tribehenin, tridecyl neopentanoate, tridecyl stearate,triethanolamine, tristearin, urea, vegetable oil, water, waxes, wheat(triticum vulgare) germ oil, and ylang ylang (cananga odorata) oil.

c. Antioxidants

Non-limiting examples of antioxidants that can be used with thecompositions of the present invention include acetyl cysteine, ascorbicacid polypeptide, ascorbyl dipalmitate, ascorbyl methylsilanolpectinate, ascorbyl palmitate, ascorbyl stearate, BHA, BHT, t-butylhydroquinone, cysteine, cysteine HCI, diamylhydroquinone,di-t-butylhydroquinone, dicetyl thiodipropionate, dioleyl tocopherylmethylsilanol, disodium ascorbyl sulfate, distearyl thiodipropionate,ditridecyl thiodipropionate, dodecyl gallate, erythorbic acid, esters ofascorbic acid, ethyl ferulate, ferulic acid, gallic acid esters,hydroquinone, isooctyl thioglycolate, kojic acid, magnesium ascorbate,magnesium ascorbyl phosphate, methylsilanol ascorbate, natural botanicalanti-oxidants such as green tea or grape seed extracts,nordihydroguaiaretic acid, octyl gallate, phenylthioglycolic acid,potassium ascorbyl tocopheryl phosphate, potassium sulfite, propylgallate, quinones, rosmarinic acid, sodium ascorbate, sodium bisulfite,sodium erythorbate, sodium metabisulfite, sodium sulfite, superoxidedismutase, sodium thioglycolate, sorbityl furfural, thiodiglycol,thiodiglycolamide, thiodiglycolic acid, thioglycolic acid, thiolacticacid, thiosalicylic acid, tocophereth-5, tocophereth-10, tocophereth-12,tocophereth-18, tocophereth-50, tocopherol, tocophersolan, tocopherylacetate, tocopheryl linoleate, tocopheryl nicotinate, tocopherylsuccinate, and tris(nonylphenyl)phosphite.

d. Structuring Agents

In other non-limiting aspects, the compositions of the present inventioncan include a structuring agent. Structuring agent, in certain aspects,assist in providing rheological characteristics to the composition tocontribute to the composition's stability. In other aspects, structuringagents can also function as an emulsifier or surfactant. Non-limitingexamples of structuring agents include stearic acid, palmitic acid,stearyl alcohol, cetyl alcohol, behenyl alcohol, stearic acid, palmiticacid, the polyethylene glycol ether of stearyl alcohol having an averageof about 1 to about 21 ethylene oxide units, the polyethylene glycolether of cetyl alcohol having an average of about 1 to about 5 ethyleneoxide units, and mixtures thereof.

e. Emulsifiers

In certain aspects of the present invention, the compositions do notinclude an emulsifier. In other aspects, however, the compositions caninclude one or more emulsifiers. Emulsifiers can reduce the interfacialtension between phases and improve the formulation and stability of anemulsion. The emulsifiers can be nonionic, cationic, anionic, andzwitterionic emulsifiers (See McCutcheon's (1986); U.S. Pat. Nos.5,011,681; 4,421,769; 3,755,560). Non-limiting examples include estersof glycerin, esters of propylene glycol, fatty acid esters ofpolyethylene glycol, fatty acid esters of polypropylene glycol, estersof sorbitol, esters of sorbitan anhydrides, carboxylic acid copolymers,esters and ethers of glucose, ethoxylated ethers, ethoxylated alcohols,alkyl phosphates, polyoxyethylene fatty ether phosphates, fatty acidamides, acyl lactylates, soaps, TEA stearate, DEA oleth-3 phosphate,polyethylene glycol 20 sorbitan monolaurate (polysorbate 20),polyethylene glycol 5 soya sterol, steareth-2, steareth-20, steareth-21,ceteareth-20, PPG-2 methyl glucose ether distearate, ceteth-10,polysorbate 80, cetyl phosphate, potassium cetyl phosphate,diethanolamine cetyl phosphate, polysorbate 60, glyceryl stearate,PEG-100 stearate, and mixtures thereof.

f. Silicone Containing Compounds

In non-limiting aspects, silicone containing compounds include anymember of a family of polymeric products whose molecular backbone ismade up of alternating silicon and oxygen atoms with side groupsattached to the silicon atoms. By varying the —Si—O— chain lengths, sidegroups, and crosslinking, silicones can be synthesized into a widevariety of materials. They can vary in consistency from liquid to gel tosolids.

The silicone containing compounds that can be used in the context of thepresent invention include those described in this specification or thoseknown to a person of ordinary skill in the art. Non-limiting examplesinclude silicone oils (e.g., volatile and non-volatile oils), gels, andsolids. In certain aspects, the silicon containing compounds includes asilicone oils such as a polyorganosiloxane. Non-limiting examples ofpolyorganosiloxanes include dimethicone, cyclomethicone,polysilicone-11, phenyl trimethicone, trimethylsilylamodimethicone,stearoxytrimethylsilane, or mixtures of these and other organosiloxanematerials in any given ratio in order to achieve the desired consistencyand application characteristics depending upon the intended application(e.g., to a particular area such as the skin, hair, or eyes). A“volatile silicone oil” includes a silicone oil have a low heat ofvaporization, i.e. normally less than about 50 cal per gram of siliconeoil. Non-limiting examples of volatile silicone oils include:cyclomethicones such as Dow Corning 344 Fluid, Dow Corning 345 Fluid,Dow Corning 244 Fluid, and Dow Corning 245 Fluid, Volatile Silicon 7207(Union Carbide Corp., Danbury, Conn.); low viscosity dimethicones, i.e.dimethicones having a viscosity of about 50 cst or less (e.g.,dimethicones such as Dow Corning 200-0.5 cst Fluid). The Dow CorningFluids are available from Dow Corning Corporation, Midland, Mich.Cyclomethicone and dimethicone are described in the Third Edition of theCTFA Cosmetic Ingredient Dictionary (incorporated by reference) ascyclic dimethyl polysiloxane compounds and a mixture of fully methylatedlinear siloxane polymers end-blocked with trimethylsiloxy units,respectively. Other non-limiting volatile silicone oils that can be usedin the context of the present invention include those available fromGeneral Electric Co., Silicone Products Div., Waterford, N.Y. and SWSSilicones Div. of Stauffer Chemical Co., Adrian, Mich.

g. Essential Oils

Essential oils include oils derived from herbs, flowers, trees, andother plants. Such oils are typically present as tiny droplets betweenthe plant's cells, and can be extracted by several method known to thoseof skill in the art (e.g., steam distilled, enfleurage (i.e., extractionby using fat), maceration, solvent extraction, or mechanical pressing).When these types of oils are exposed to air they tend to evaporate(i.e., a volatile oil). As a result, many essential oils are colorless,but with age they can oxidize and become darker. Essential oils areinsoluble in water and are soluble in alcohol, ether, fixed oils(vegetal), and other organic solvents. Typical physical characteristicsfound in essential oils include boiling points that vary from about 160°to 240° C. and densities ranging from about 0.759 to about 1.096.

Essential oils typically are named by the plant from which the oil isfound. For example, rose oil or peppermint oil are derived from rose orpeppermint plants, respectively. Non-limiting examples of essential oilsthat can be used in the context of the present invention include sesameoil, macadamia nut oil, tea tree oil, evening primrose oil, Spanish sageoil, Spanish rosemary oil, coriander oil, thyme oil, pimento berriesoil, rose oil, anise oil, balsam oil, bergamot oil, rosewood oil, cedaroil, chamomile oil, sage oil, clary sage oil, clove oil, cypress oil,eucalyptus oil, fennel oil, sea fennel oil, frankincense oil, geraniumoil, ginger oil, grapefruit oil, jasmine oil, juniper oil, lavender oil,lemon oil, lemongrass oil, lime oil, mandarin oil, marjoram oil, myrrhoil, neroli oil, orange oil, patchouli oil, pepper oil, black pepperoil, petitgrain oil, pine oil, rose otto oil, rosemary oil, sandalwoodoil, spearmint oil, spikenard oil, vetiver oil, wintergreen oil, orylang ylang. Other essential oils known to those of skill in the art arealso contemplated as being useful within the context of the presentinvention.

h. Thickening Agents

Thickening agents, including thickener or gelling agents, includesubstances which that can increase the viscosity of a composition.Thickeners includes those that can increase the viscosity of acomposition without substantially modifying the efficacy of the activeingredient within the composition. Thickeners can also increase thestability of the compositions of the present invention. In certainaspects of the present invention, thickeners include hydrogenatedpolyisobutene or trihydroxystearin, or a mixture of both.

Non-limiting examples of additional thickening agents that can be usedin the context of the present invention include carboxylic acidpolymers, crosslinked polyacrylate polymers, polyacrylamide polymers,polysaccharides, and gums. Examples of carboxylic acid polymers includecrosslinked compounds containing one or more monomers derived fromacrylic acid, substituted acrylic acids, and salts and esters of theseacrylic acids and the substituted acrylic acids, wherein thecrosslinking agent contains two or more carbon-carbon double bonds andis derived from a polyhydric alcohol (see U.S. Pat. Nos. 5,087,445;4,509,949; 2,798,053; CTFA International Cosmetic Ingredient Dictionary,Fourth edition, 1991, pp. 12 and 80). Examples of commercially availablecarboxylic acid polymers include carbomers, which are homopolymers ofacrylic acid crosslinked with allyl ethers of sucrose or pentaerytritol(e.g., Carbopol™ 900 series from B. F. Goodrich).

Non-limiting examples of crosslinked polyacrylate polymers includecationic and nonionic polymers. Examples are described in U.S. Pat. Nos.5,100,660 ; 4,849,484; 4,835,206; 4,628,078; 4,599,379).

Non-limiting examples of polyacrylamide polymers (including nonionicpolyacrylamide polymers including substituted branched or unbranchedpolymers) include polyacrylamide, isoparaffin and laureth-7, multi-blockcopolymers of acrylamides and substituted acrylamides with acrylic acidsand substituted acrylic acids.

Non-limiting examples of polysaccharides include cellulose,carboxymethyl hydroxyethylcellulose, cellulose acetate propionatecarboxylate, hydroxyethylcellulose, hydroxyethyl ethylcellulose,hydroxypropylcellulose, hydroxypropyl methylcellulose, methylhydroxyethylcellulose, microcrystalline cellulose, sodium cellulosesulfate, and mixtures thereof. Another example is an alkyl substitutedcellulose where the hydroxy groups of the cellulose polymer ishydroxyalkylated (preferably hydroxy ethylated or hydroxypropylated) toform a hydroxyalkylated cellulose which is then further modified with aC₁₀ -C₃₀ straight chain or branched chain alkyl group through an etherlinkage. Typically these polymers are ethers of C₁₀-C₃₀ straight orbranched chain alcohols with hydroxyalkylcelluloses. Other usefulpolysaccharides include scleroglucans comprising a linear chain of (1-3)linked glucose units with a (1-6) linked glucose every three unit.

Non-limiting examples of gums that can be used with the presentinvention include acacia, agar, algin, alginic acid, ammonium alginate,amylopectin, calcium alginate, calcium carrageenan, carnitine,carrageenan, dextrin, gelatin, gellan gum, guar gum, guarhydroxypropyltrimonium chloride, hectorite, hyaluroinic acid, hydratedsilica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp,locust bean gum, natto gum, potassium alginate, potassium carrageenan,propylene glycol alginate, sclerotium gum, sodium carboyxmethyl dextran,sodium carrageenan, tragacanth gum, xanthan gum, and mixtures thereof.

i. Preservatives

Non-limiting examples of preservatives that can be used in the contextof the present invention include quaternary ammonium preservatives suchas polyquaternium-1 and benzalkonium halides (e.g., benzalkoniumchloride (“BAC”) and benzalkonium bromide), parabens (e.g.,methylparabens and propylparabens), phenoxyethanol, benzyl alcohol,chlorobutanol, phenol, sorbic acid, thimerosal or combinations thereof.

2. Pharmaceutical Ingredients

Pharmaceutical active agents are also contemplated as being useful withthe compositions of the present invention. Non-limiting examples ofpharmaceutical active agents include anti-acne agents, agents used totreat rosacea, analgesics, anesthetics, anorectals, antihistamines,anti-inflammatory agents including non-steroidal anti-inflammatorydrugs, antibiotics, antifungals, antivirals, antimicrobials, anti-canceractives, scabicides, pediculicides, antineoplastics, antiperspirants,antipruritics, antip soriatic agents, anti seborrheic agents,biologically active proteins and peptides, burn treatment agents,cauterizing agents, depigmenting agents, depilatories, diaper rashtreatment agents, enzymes, hair growth stimulants, hair growthretardants including DFMO and its salts and analogs, hemostatics,kerotolytics, canker sore treatment agents, cold sore treatment agents,dental and periodontal treatment agents, photosensitizing actives, skinprotectant/barrier agents, steroids including hormones andcorticosteroids, sunburn treatment agents, sunscreens, transdermalactives, nasal actives, vaginal actives, wart treatment agents, woundtreatment agents, wound healing agents, etc.

D. Kits

Kits are also contemplated as being used in certain aspects of thepresent invention. For instance, compositions of the present inventioncan be included in a kit. A kit can include a container. Containers caninclude a bottle, a metal tube, a laminate tube, a plastic tube, adispenser, a pressurized container, a barrier container, a package, acompartment, a lipstick container, a compact container, cosmetic pansthat can hold cosmetic compositions, or other types of containers suchas injection or blow-molded plastic containers into which thedispersions or compositions or desired bottles, dispensers, or packagesare retained. The kit and/or container can include indicia on itssurface. The indicia, for example, can be a word, a phrase, anabbreviation, a picture, or a symbol.

The containers can dispense a pre-determined amount of the composition.In other embodiments, the container can be squeezed (e.g., metal,laminate, or plastic tube) to dispense a desired amount of thecomposition. The composition can be dispensed as a spray, an aerosol, aliquid, a fluid, or a semi-solid. The containers can have spray, pump,or squeeze mechanisms. A kit can also include instructions for employingthe kit components as well the use of any other compositions included inthe container. Instructions can include an explanation of how to apply,use, and maintain the compositions.

EXAMPLES

The following examples are included to demonstrate certain non-limitingaspects of the invention. It should be appreciated by those of skill inthe art that the techniques disclosed in the examples which followrepresent techniques discovered by the inventor to function well in thepractice of the invention. However, those of skill in the art should, inlight of the present disclosure, appreciate that many changes can bemade in the specific embodiments which are disclosed and still obtain alike or similar result without departing from the spirit and scope ofthe invention.

Example 1 Formulations

The formulations in Tables 1 and 2 are each moisturizers, theformulations in Tables 3 and 4 are each eye treatment formulations, theformulation in Table 5 is a cleanser, and the formulation in Table 6 isan aqueous gel-based serum capable of moisturizing the skin.

TABLE 1* Ingredient % Concentration (by weight) Water 39 to 46.5Oxybenzone 4 Octisalate 4.5 Octocrylene 2 to 3 Homosalate 6 Avobenzone 2Styrene/acrylates copolymer 1.7 .75 Glycerin 2.5 To 5 Butylene glycol 1to 3 Ethylene/acrylic acid copolymer 0.5 Buyrospermum parkii butter 0.5Disodium EDTA 0.23 Triethanolamine 0.05 to 0.55 Glycereth-26 4 Allantoin0.08 Xantham gum 0.25 Panthenol 0.1 Tocopherol acetate 0.1 Sodium PCA0.05 to 0.1 Benzyl alcohol 0.9 PEG-100 stearate 0.7 to 0.8 Lauramineoxide 0.2 to 0.9 C9-15 alkyl phosphate 0.11 Polymethylsilsesquioxane 1Methyl trimethicone 0.6 Acrylates/dimethicone copolymer 0.4 Excipients**q.s. *Formulation can be prepared by mixing the ingredients in a beakerunder heat 70-75° C. until homogenous. Subsequently, the formulation canbe cooled to standing room temperature (20-25° C.). **Excipients can beadded, for example, to modify the rheological properties of thecomposition. Alternatively, the amount of water can be varied so long asthe amount of water in the composition is at least 30% w/w, andpreferably between 35 to 85% w/w.

TABLE 2* Ingredient % Concentration (by weight) Water 43.5 Homosalate 6Octisalate 4.5 Oxybenzone 4 Octocrylene 3 Avobenzone 2 Styrene/acrylatescopolymer 1.7 Glycerin 5 Glycereth-26 4 Butylene glycol 3 Trisiloxane2.5 C12-15 alkyl benzoate 2.1 Butyloctyl salicylate 2 Glyceryl stearate1 Benzyl alcohol 0.9 Phenoxyethanol 0.8 Arachidyl alcohol 0.6 Caprylylglycol 0.6 Dimethicone 0.5 Ethylene/acrylic acid copolymer 0.5Butyrospermum parkii 0.5 Disodium EDTA 0.2 Triethanolamine 0.08 Optuniatuna fruit extract 0.0005 Excipients q.s. *Formulation can be preparedby mixing the ingredients in a beaker under heat 70-75° C. untilhomogenous. Subsequently, the formulation can be cooled to standing roomtemperature (20-25° C.). **Excipients can be added, for example, tomodify the rheological properties of the composition. Alternatively, theamount of water can be varied so long as the amount of water in thecomposition is at least 35% w/w, and preferably between 40 to 85% w/w.

TABLE 3* Ingredient % Concentration (by weight) Water 62 Glycerin 1.5Butylene Glycol 5 Betaine 4 Triethanolamine 0.5 Dimethicone 1 DisodiumEDTA 0.05 Phenoxyethanol 0.9 Butyrospermum parkii 4 Ethylene/acrylicacid copolymer 2 Palmitoyl tetrapeptide-7 2 Hydrogenated polydecene 2.25Polyethylene 2.25 Cetyl esters 1.25 Behenyl alcohol 1.25 C12-15 alcoholsbenzoate 2 Excipients** q.s. *Formulation can be prepared by mixing theingredients in a beaker under heat 70-75° C. until homogenous.Subsequently, the formulation can be cooled to standing room temperature(20-25° C.). **Excipients can be added, for example, to modify therheological properties of the composition. Alternatively, the amount ofwater can be varied so long as the amount of water in the composition isat least 60% w/w, and preferably between 60 to 85% w/w.

TABLE 4* Ingredient % Concentration (by weight) Water 62 Glycerin 1.5Butylene Glycol 5 Betaine 4 Triethanolamine 0.5 Dimethicone 1 DisodiumEDTA 0.05 Phenoxyethanol 0.9 Butyrospermum parkii 4 Ethylene/acrylicacid copolymer 2 Palmitoyl tetrapeptide-7 2 Hydrogenated polydecene 2.25Polyethylene 2.25 Cetyl esters 1.25 Behenyl alcohol 1.25 C12-15 alcoholsbenzoate 2 Optunia tuna fruit extract 0.05 Excipients** q.s.*Formulation can be prepared by mixing the ingredients in a beaker underheat 70-75° C. until homogenous. Subsequently, the formulation can becooled to standing room temperature (20-25° C.). **Excipients can beadded, for example, to modify the rheological properties of thecomposition. Alternatively, the amount of water can be varied so long asthe amount of water in the composition is at least 60% w/w, andpreferably between 60 to 85% w/w.

TABLE 5* Ingredient % Concentration (by weight) water 75 glycerin 3triethanolamine 0.8 phenoxyethanol 0.7 disodium EDTA 0.1 hydroxypropylcyclodextrin 0.07 iodopropynyl butylcarbamate 0.009 tea-lauryl sulfate 8cocamidopropyl betaine 2.4 propylene glycol 2 sodium methyl cocoyltaurate 1.5 dimethicone 1 lauramine oxide 0.9 acrylates/C10-30 alkylacrylate 0.75 crosspolymer sodium chloride 0.7 caprylyl glycol 0.6C12-15 alkyl benzoate 0.5 benzyl alcohol 0.5 PEG-150 distearate 0.5PPG-26-buteth-26 0.3 PEG-40 hydrogenated castor oil 0.2 Excipients**q.s. *Formulation can be prepared by mixing the ingredients in a beakerunder heat 70-75° C. until homogenous. **Excipients can be added, forexample, to modify the rheological properties of the composition.Alternatively, the amount of water can be varied so long as the amountof water in the composition is at least 60% w/w, and preferably between60 to 85% w/w.

TABLE 6* Ingredient % Concentration (by weight) water 88 glycerin 1.6triethanolamine 0.25 phenoxyethanol 0.9 disodium EDTA 0.1 hydroxypropylcyclodextrin 0.07 iodopropynyl butylcarbamate 0.009 butylene glycol 6.3niacinamide 2 hydroxypropyl cyclodextrin 0.07 adenosine 0.04 acetyldipeptide-1 cetyl ester 0.01 palmitoyl oligopeptide 0.0003 palmitoyltetrapeptide-7 0.0001 acrylates/vinyl isodecanoate 0.25 crosspolymerhydroxyethylcellulose 0.22 Excipients** q.s. *Formulation can beprepared by mixing the ingredients in a beaker under heat 70-75° C.until homogenous. **Excipients can be added, for example, to modify therheological properties of the composition. Alternatively, the amount ofwater can be varied so long as the amount of water in the composition isat least 60% w/w, and preferably between 60 to 95% w/w.

A formulation having the characteristics of the Table 1 formulation, theTable 2 formulation, the Table 5 formulation, or the Table 6 formulationcan be used in a regimen that also includes an eye care formulation. Aformulation having the characteristics of the Table 3 formulation, theTable 4 formulation, the Table 5 formulation, or the Table 6 formulationcan be used in a regimen that also includes a moisturizer ormoisturizing sunscreen formulation. A formulation having thecharacteristics of the Table 1 formulation, the Table 2 formulation, theTable 3 formulation, the Table 4 formulation, or the Table 6 formulationformulations can be used in a regiment that also includes a skincleanser. A formulation having the characteristics of the Table 1formulation, the Table 2 formulation, the Table 3 formulation, the Table4 formulation, or the Table 5 formulation can be used in a regimen thatalso includes a serum that is capable of moisturizing the skin.

The ingreidnets niacinamide, acetyl dipeptide-1 cetyl ester, palmitoyloligopeptide, and palmitoyl tetrapeptide-7 were individually tested andfound to have benefical properties for skin. The data for theseingredients are summarized in Table 7.

TABLE 7 Ingredient Data Acetyl dipeptide-1 Cetyl Ester (suppied byInhibit IL-1α & TNF-α Production by Sederma under the tradenameCalmosensine) Human Epidermal Keratinocytes (IL-1α −97% inhibition)(TNF-α −88%) Palmitoyl oligopeptide with palmitoyl Stimulates collagensynthesis by fibroblasts tetrapeptide-7 (supplied by Sederma undercultures. the tradename Matrixyl 3000) Niacinamide InhibitsMelanogenesis with Mouse Melanocytes (B16-F1 Assay) (−28%)

Tumor Necrosis Factor Alpha (TNF-α) Assay: The prototype ligand of theTNF superfamily, TNF-α, is a pleiotropic cytokine that plays a centralrole in inflammation. Increase in its expression is associated with anup regulation in pro-inflammatory activity. This bioassay can be used toanalyze the effect of any one of the active ingredients, combination ofingredients, or compositions having said combinations disclosed in thespecification on the production of TNF-α by human epidermalkeratinocytes. The endpoint of this assay can be a spectrophotometricmeasurement that reflects the presence of TNF-α and cellular viability.The assay employs the quantitative sandwich enzyme immunoassay techniquewhereby a monoclonal antibody specific for TNF-α has been pre-coatedonto a microplate. Standards and samples can be pipetted into the wellsand any TNF-α present is bound by the immobilized antibody. Afterwashing away any unbound substances, an enzyme-linked polyclonalantibody specific for TNF-α can be added to the wells. Following a washto remove any unbound antibody-enzyme reagent, a substrate solution canbe added to the wells and color develops in proportion to the amount ofTNF-α bound in the initial step using a microplate reader for detectionat 450 nm. The color development can be stopped and the intensity of thecolor can be measured. Subconfluent normal human adult keratinocytes(Cascade Biologics) cultivated in EpiLife standard growth medium(Cascade Biologics) at 37° C. in 5% CO₂, can be treated with phorbol12-myristate 13-acetate (PMA, 10 ng/ml, Sigma Chemical, #P1585-1 MG) andany one of the active ingredients, combination of ingredients, orcompositions having said combinations disclosed in the specification for6 hours. PMA has been shown to cause a dramatic increase in TNF-αsecretion which peaks at 6 hours after treatment. Following incubation,cell culture medium can be collected and the amount of TNF-α secretionquantified using a sandwich enzyme linked immuno-sorbant assay (ELISA)from R&D Systems (#DTA00C).

B16 Pigmentation Assay: Melanogenesis is the process by whichmelanocytes produce melanin, a naturally produced pigment that impartscolor to skin, hair, and eyes. Inhibiting melanogenesis is beneficial toprevent skin darkening and lighten dark spots associated with aging.This bioassay utilizes B16-F1 melanocytes (ATCC), an immortalized mousemelanoma cell line, to analyze the effect of compounds on melanogenesis.The endpoint of this assay is a spectrophotometric measurement ofmelanin production and cellular viability. B16-F1 melanocytes, can becultivated in standard DMEM growth medium with 10% fetal bovine serum(Mediatech) at 37° C. in 10% CO₂ and then treated with any one of theactive ingredients, combination of ingredients ,or compositions havingsaid combinations disclosed in the specification for 6 days. Followingincubation, melanin secretion was measured by absorbance at 405 nm andcellular viability was quantified.

IL-1α Assay: A quantitative sandwich enzyme immunoassay technique(ELISA)was used to measure IL-1α in cell culture supernates. A monoclonalantibody that is specific for IL-1α was pre-coated onto a microplate.Standards and treatment samples are then pipetted into the wells and anyIL-1α present is bound by the immobilized antibody. After washing awayany unbound substances, an enzyme-linked polyclonal antibody specificfor IL-1α is added to the wells. Following a wash to remove any unboundantibody-enzyme reagent, a substrate solution is added to the wells andcolor develops in proportion to the amount of IL-1α bound which wassecreted in response to the treatment.

Example 2 Assays

Additional assays that can be used to determine the efficacy of any oneof the ingredients or any combination of ingredients or compositionshaving said combination of ingredients disclosed throughout thespecification and claims can be determined by methods known to those ofordinary skill in the art. The following are non-limiting assays thatcan be used in the context of the present invention. It should berecognized that other testing procedures can be used, including, forexample, objective and subjective procedures.

Collagen Stimulation Assay: Collagen is an extracellular matrix proteincritical for skin structure. Increased synthesis of collagen helpsimprove skin firmness and elasticity. This bioassay can be used toexamine the effect of any one of the active ingredients, combination ofingredients, or compositions having said combinations disclosed in thespecification on the production of procollagen peptide (a precursor tocollagen) by human epidermal fibroblasts. The endpoint of this assay isa spectrophotometric measurement that reflects the presence ofprocollagen peptide and cellular viability. The assay employs thequantitative sandwich enzyme immunoassay technique whereby a monoclonalantibody specific for procollagen peptide has been pre-coated onto amicroplate. Standards and samples can be pipetted into the wells and anyprocollagen peptide present is bound by the immobilized antibody. Afterwashing away any unbound substances, an enzyme-linked polyclonalantibody specific for procollagen peptide can be added to the wells.Following a wash to remove any unbound antibody-enzyme reagent, asubstrate solution can be added to the wells and color develops inproportion to the amount of procollagen peptide bound in the initialstep using a microplate reader for detection at 450 nm. The colordevelopment can be stopped and the intensity of the color can bemeasured. Subconfluent normal human adult epidermal fibroblasts (CascadeBiologics) cultivated in standard DMEM growth medium with 10% fetalbovine serum (Mediatech) at 37° C. in 10% CO₂, can be treated with eachof the combination of ingredients or compositions having saidcombinations disclosed in the specification for 3 days. Followingincubation, cell culture medium can be collected and the amount ofprocollagen peptide secretion quantified using a sandwich enzyme linkedimmuno-sorbant assay (ELISA) from Takara (#MK101).

Antioxidant (AO) assay: An in vitro bioassay that measures the totalanti-oxidant capacity of any one of the ingredients, combination ofingredients, or compositions having said combinations disclosed in thespecification. The assay relies on the ability of antioxidants in thesample to inhibit the oxidation of ABTS®(2,2′-azino-di-[3-ethylbenzthiazoline sulphonate]) to ABTS®⋅+ bymetmyoglobin. The antioxidant system of living organisms includesenzymes such as superoxide dismutase, catalase, and glutathioneperoxidase; macromolecules such as albumin, ceruloplasmin, and ferritin;and an array of small molecules, including ascorbic acid, α-tocopherol,β-carotene, reduced glutathione, uric acid, and bilirubin. The sum ofendogenous and food-derived antioxidants represents the totalantioxidant activity of the extracellular fluid. Cooperation of all thedifferent antioxidants provides greater protection against attack byreactive oxygen or nitrogen radicals, than any single compound alone.Thus, the overall antioxidant capacity may give more relevant biologicalinformation compared to that obtained by the measurement of individualcomponents, as it considers the cumulative effect of all antioxidantspresent in plasma and body fluids. The capacity of the antioxidants inthe sample to prevent ABTS oxidation is compared with that of Trolox, awater-soluble tocopherol analogue, and is quantified as molar Troloxequivalents. Anti-Oxidant capacity kit #709001 from Cayman Chemical (AnnArbor, Mich. USA) can be used as an in vitro bioassay to measure thetotal anti-oxidant capacity of each of any one of the activeingredients, combination of ingredients, or compositions having saidcombinations disclosed in the specification. The protocol can befollowed according to manufacturer recommendations. The assay relied onantioxidants in the sample to inhibit the oxidation of ABTS®(2,2′-azino-di-[3-ethylbenzthiazoline sulphonate]) to ABTS®⋅+ bymetmyoglobin. The capacity of the antioxidants in the sample to preventABTS oxidation can be compared with that Trolox, a water-solubletocopherol analogue, and was quantified as a molar Trolox equivalent.

ORAC Assay: Oxygen Radical Absorption (or Absorbance) Capacity (ORAC) ofany one of the active ingredients, combination of ingredients, orcompositions having said combinations disclosed in the specification canalso be assayed by measuring the antioxidant activity of suchingredients or compositions. This assay can quantify the degree andlength of time it takes to inhibit the action of an oxidizing agent suchas oxygen radicals that are known to cause damage cells (e.g., skincells). The ORAC value of any one of the active ingredients, combinationof ingredients, or compositions having said combinations disclosed inthe specification can be determined by methods known to those ofordinary skill in the art (see U.S. Publication Nos. 2004/0109905 and2005/0163880; Cao et al. (1993)), all of which are incorporated byreference). In summary, the assay described in Cao et al. (1993)measures the ability of antioxidant compounds in test materials toinhibit the decline of B-phycoerythrm (B-PE) fluorescence that isinduced by a peroxyl radical generator, AAPH.

Mushroom tyrosinase activity assay: In mammalian cells, tyrosinasecatalyzes two steps in the multi-step biosynthesis of melanin pigmentsfrom tyrosine (and from the polymerization of dopachrome). Tyrosinase islocalized in melanocytes and produces melanin (aromatic quinonecompounds) that imparts color to skin, hair, and eyes. Purified mushroomtyrosinase (Sigma) can be incubated with its substrate L-Dopa (Fisher)in the presence or absence of each of the active ingredients, any one ofthe combination of ingredients, or compositions having said combinationsdisclosed in the specification. Pigment formation can be evaluated bycolorimetric plate reading at 490 nm. The percent inhibition of mushroomtyrosinase activity can be calculated compared to non-treated controlsto determine the ability of test ingredients or combinations thereof toinhibit the activity of purified enzyme. Test extract inhibition wascompared with that of kojic acid (Sigma).

Matrix Metalloproteinase Enzyme Activity (MMP3; MMP9) Assay: An in vitromatrix metalloprotease (MMP) inhibition assay. MMPs are extracellularproteases that play a role in many normal and disease states by virtueof their broad substrate specificity. MMP3 substrates include collagens,fibronectins, and laminin; while MMP9 substrates include collagen VII,fibronectins and laminin. Using Colorimetric Drug Discovery kits fromBioMol International for MMP3 (AK-400) and MMP-9 (AK-410), this assay isdesigned to measure protease activity of MMPs using a thiopeptide as achromogenic substrate (Ac-PLG-[2-mercapto-4-methyl-pentanoyl]-LG-OC2H5)5,6. The MMP cleavage site peptide bond isreplaced by a thioester bond in the thiopeptide. Hydrolysis of this bondby an MMP produces a sulfhydryl group, which reacts with DTNB[5,5′-dithiobis(2- nitrobenzoic acid), Ellman's reagent] to form2-nitro-5- thiobenzoic acid, which can be detected by its absorbance at412 nm (ε=13,600 M-1 cm-1 at pH 6.0 and above 7). The activeingredients, any one of the combination of ingredients, or compositionshaving said combinations disclosed in the specification can be assayed.

Cyclooxygenase (COX) Assay: An in vitro cyclooxygenase-1 and -2(COX-1,-2) inhibition assay. COX is a bifunctional enzyme exhibitingboth cyclooxygenase and peroxidase activities. The cyclooxygenaseactivity converts arachidonic acid to a hydroperoxy endoperoxide(Prostaglandin G2; PGG2) and the peroxidase component reduces theendoperoxide (Prostaglandin H2; PGH2) to the corresponding alcohol, theprecursor of prostaglandins, thromboxanes, and prostacyclins. This COXInhibitor screening assay measures the peroxidase component ofcyclooxygenases. The peroxidase activity is assayed colorimetrically bymonitoring the appearance of oxidizedN,N,N′,N′-tetramethyl-p-phenylenediamine (TMPD). This inhibitorscreening assay includes both COX-1 and COX-2 enzymes in order to screenisozyme-specific inhibitors. The Colormetric COX (ovine) Inhibitorscreening assay (#760111, Cayman Chemical) can be used to analyze theeffects of each of the active ingredients, any one of the combination ofingredients, or compositions having said combinations disclosed in thespecification on the activity of purified cyclooxygnase enzyme (COX-1 orCOX-2). According to manufacturer instructions, purified enzyme, hemeand test extracts can be mixed in assay buffer and incubated withshaking for 15 min at room temperature. Following incubation,arachidonic acid and colorimetric substrate can be added to initiate thereaction. Color progression can be evaluated by colorimetric platereading at 590 nm. The percent inhibition of COX-1 or COX-2 activity canbe calculated compared to non-treated controls to determine the abilityof test extracts to inhibit the activity of purified enzyme.

Lipoxygenase (LO) Assay: An in vitro lipoxygenase (LO) inhibition assay.LOs are non-heme iron-containing dioxygenases that catalyze the additionof molecular oxygen to fatty acids. Linoleate and arachidonate are themain substrates for LOs in plants and animals. Arachadonic acid may thenbe converted to hydroxyeicosotrienenoic (HETE) acid derivatives, thatare subsequently converted to leukotirenes, potent inflammatorymediators. This assay provides an accurate and convenient method forscreening lipoxygenase inhibitors by measuring the hydroperoxidesgenerated from the incubation of a lipoxygenase (5-, 12-, or 15-LO) witharachidonic acid. The Colorimetric LO Inhibitor screening kit (#760700,Cayman Chemical) can be used to determine the ability of each of theactive ingredients, any one of the combination of ingredients, orcompositions having said combinations disclosed in the specification toinhibit enzyme activity. Purified 15-lipoxygenase and test ingredientscan be mixed in assay buffer and incubated with shaking for 10 min atroom temperature. Following incubation, arachidonic acid can be added toinitiate the reaction and mixtures incubated for an additional 10 min atroom temperature. Colorimetric substrate can be added to terminatecatalysis and color progression was evaluated by fluorescence platereading at 490 nm. The percent inhibition of lipoxyganse activity can becalculated compared to non-treated controls to determine the ability ofeach of the active ingredients, any one of the combination ofingredients, or compositions having said combinations disclosed in thespecification to inhibit the activity of purified enzyme.

Elastase Assay: EnzChek® Elastase Assay (Kit# E-12056) from MolecularProbes (Eugene, Oreg. USA) can be used as an in vitro enzyme inhibitionassay for measuring inhibition of elastase activity for each of theactive ingredients, any one of the combination of ingredients, orcompositions having said combinations disclosed in the specification.The EnzChek kit contains soluble bovine neck ligament elastin that canbe labeled with dye such that the conjugate's fluorescence can bequenched. The non-fluorescent substrate can be digested by elastase orother proteases to yield highly fluorescent fragments. The resultingincrease in fluorescence can be monitored with a fluorescence microplatereader. Digestion products from the elastin substrate have absorptionmaxima at ˜505 nm and fluorescence emission maxima at ˜515 nm. Thepeptide, chloromethyl ketone, can be used as a selective, collectiveinhibitor of elastase when utilizing the EnzChek Elastase Assay Kit forscreening for elastase inhibitors.

Oil Control Assay: An assay to measure reduction of sebum secretion fromsebaceous glands and/or reduction of sebum production from sebaceousglands can be assayed by using standard techniques known to those havingordinary skill in the art. In one instance, the forehead can be used.Each of the active ingredients, any one of the combination ofingredients, or compositions having said combinations disclosed in thespecification can be applied to one portion of the forehead once ortwice daily for a set period of days (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9,10, 11, 12, 13, 14, or more days), while another portion of the foreheadis not treated with the composition. After the set period of daysexpires, then sebum secretion can be assayed by application of fineblotting paper to the treated and untreated forehead skin. This is doneby first removing any sebum from the treated and untreated areas withmoist and dry cloths. Blotting paper can then be applied to the treatedand untreated areas of the forehead, and an elastic band can be placedaround the forehead to gently press the blotting paper onto the skin.After 2 hours the blotting papers can be removed, allowed to dry andthen transilluminated. Darker blotting paper correlates with more sebumsecretion (or lighter blotting paper correlates with reduced sebumsecretion.

Erythema Assay: An assay to measure the reduction of skin redness can beevaluated using a Minolta Chromometer. Skin erythema may be induced byapplying a 0.2% solution of sodium dodecyl sulfate on the forearm of asubject. The area is protected by an occlusive patch for 24 hrs. After24 hrs, the patch is removed and the irritation-induced redness can beassessed using the a* values of the Minolta Chroma Meter. The a* valuemeasures changes in skin color in the red region. Immediately afterreading, the area is treated with the active ingredients, any one of thecombination of ingredients, or compositions having said combinationsdisclosed in the specification. Repeat measurements can be taken atregular intervals to determine the formula's ability to reduce rednessand irritation.

Skin Moisture/Hydration Assay: Skin moisture/hydration benefits can bemeasured by using impedance measurements with the Nova Dermal PhaseMeter. The impedance meter measures changes in skin moisture content.The outer layer of the skin has distinct electrical properties. Whenskin is dry it conducts electricity very poorly. As it becomes morehydrated increasing conductivity results. Consequently, changes in skinimpedance (related to conductivity) can be used to assess changes inskin hydration. The unit can be calibrated according to instrumentinstructions for each testing day. A notation of temperature andrelative humidity can also be made. Subjects can be evaluated asfollows: prior to measurement they can equilibrate in a room withdefined humidity (e.g., 30-50%) and temperature (e.g., 68-72° C.). Threeseparate impedance readings can be taken on each side of the face,recorded, and averaged. The T5 setting can be used on the impedancemeter which averages the impedance values of every five secondsapplication to the face. Changes can be reported with statisticalvariance and significance. Each of the active ingredients, any one ofthe combination of ingredients, or compositions having said combinationsdisclosed in the specification can be assayed according to this process.

Skin Clarity and Reduction in Freckles and Age Spots Assay: Skin clarityand the reduction in freckles and age spots can be evaluated using aMinolta Chromometer. Changes in skin color can be assessed to determineirritation potential due to product treatment using the a* values of theMinolta Chroma Meter. The a* value measures changes in skin color in thered region. This is used to determine whether each of the activeingredients, any one of the combination of ingredients, or compositionshaving said combinations disclosed in the specification is inducingirritation. The measurements can be made on each side of the face andaveraged, as left and right facial values. Skin clarity can also bemeasured using the Minolta Meter. The measurement is a combination ofthe a*, b, and L values of the Minolta Meter and is related to skinbrightness, and correlates well with skin smoothness and hydration. Skinreading is taken as above. In one non-limiting aspect, skin clarity canbe described as L/C where C is chroma and is defined as (a²+b²)^(1/2).

Skin Dryness, Surface Fine Lines, Skin Smoothness, and Skin Tone Assay:Skin dryness, surface fine lines, skin smoothness, and skin tone can beevaluated with clinical grading techniques. For example, clinicalgrading of skin dryness can be determined by a five point standardKligman Scale: (0) skin is soft and moist; (1) skin appears normal withno visible dryness; (2) skin feels slightly dry to the touch with novisible flaking; (3) skin feels dry, tough, and has a whitish appearancewith some scaling; and (4) skin feels very dry, rough, and has a whitishappearance with scaling. Evaluations can be made independently by twoclinicians and averaged.

Clinical Grading of Skin Tone Assay: Clinical grading of skin tone canbe performed via a ten point analog numerical scale: (10) even skin ofuniform, pinkish brown color. No dark, erythremic, or scaly patches uponexamination with a hand held magnifying lens. Microtexture of the skinvery uniform upon touch; (7) even skin tone observed withoutmagnification. No scaly areas, but slight discolorations either due topigmentation or erythema. No discolorations more than 1 cm in diameter;(4) both skin discoloration and uneven texture easily noticeable. Slightscaliness. Skin rough to the touch in some areas; and (1) uneven skincoloration and texture. Numerous areas of scaliness and discoloration,either hypopigmented, erythremic or dark spots. Large areas of unevencolor more than 1 cm in diameter. Evaluations were made independently bytwo clinicians and averaged.

Clinical Grading of Skin Smoothness Assay: Clinical grading of skinsmoothness can be analyzed via a ten point analog numerical scale: (10)smooth, skin is moist and glistening, no resistance upon dragging fingeracross surface; (7) somewhat smooth, slight resistance; (4) rough,visibly altered, friction upon rubbing; and (1) rough, flaky, unevensurface. Evaluations were made independently by two clinicians andaveraged.

Skin Smoothness and Wrinkle Reduction Assay With Methods Disclosed inPackman et al. (1978): Skin smoothness and wrinkle reduction can also beassessed visually by using the methods disclosed in Packman et al.(1978). For example, at each subject visit, the depth, shallowness andthe total number of superficial facial lines (SFLs) of each subject canbe carefully scored and recorded. A numerical score was obtained bymultiplying a number factor times a depth/width/length factor. Scoresare obtained for the eye area and mouth area (left and right sides) andadded together as the total wrinkle score.

Skin Firmness Assay with a Hargens Ballistometer: Skin firmness can bemeasured using a Hargens ballistometer, a device that evaluates theelasticity and firmness of the skin by dropping a small body onto theskin and recording its first two rebound peaks. The ballistometry is asmall lightweight probe with a relatively blunt tip (4 square mm-contactarea) was used. The probe penetrates slightly into the skin and resultsin measurements that are dependent upon the properties of the outerlayers of the skin, including the stratum corneum and outer epidermisand some of the dermal layers.

Skin Softness/Suppleness Assay with a Gas Bearing Electrodynamometer:Skin softness/suppleness can be evaluated using the Gas BearingElectrodynamometer, an instrument that measures the stress/strainproperties of the skin. The viscoelastic properties of skin correlatewith skin moisturization. Measurements can be obtained on thepredetermined site on the cheek area by attaching the probe to the skinsurface with double-stick tape. A force of approximately 3.5 gm can beapplied parallel to the skin surface and the skin displacement isaccurately measured. Skin suppleness can then be calculated and isexpressed as DSR (Dynamic Spring Rate in gm/mm).

Appearance of Lines and Wrinkles Assay with Replicas: The appearance oflines and wrinkles on the skin can be evaluated using replicas, which isthe impression of the skin's surface. Silicone rubber like material canbe used. The replica can be analyzed by image analysis. Changes in thevisibility of lines and wrinkles can be objectively quantified via thetaking of silicon replicas form the subjects' face and analyzing thereplicas image using a computer image analysis system. Replicas can betaken from the eye area and the neck area, and photographed with adigital camera using a low angle incidence lighting. The digital imagescan be analyzed with an image processing program and are of the replicascovered by wrinkles or fine lines was determined.

Surface Contour of the Skin Assay with a Profilometer/Stylus Method: Thesurface contour of the skin can be measured by using theprofilometer/Stylus method. This includes either shining a light ordragging a stylus across the replica surface. The vertical displacementof the stylus can be fed into a computer via a distance transducer, andafter scanning a fixed length of replica a cross-sectional analysis ofskin profile can be generated as a two-dimensional curve. This scan canbe repeated any number of times along a fix axis to generate a simulated3-D picture of the skin. Ten random sections of the replicas using thestylus technique can be obtained and combined to generate averagevalues. The values of interest include Ra which is the arithmetic meanof all roughness (height) values computed by integrating the profileheight relative to the mean profile height. Rt which is the maximumvertical distance between the highest peak and lowest trough, and Rzwhich is the mean peak amplitude minus the mean peak height. Values aregiven as a calibrated value in mm. Equipment should be standardizedprior to each use by scanning metal standards of know values. Ra Valuecan be computed by the following equation: R_(a)=Standardize roughness;l_(m)=the traverse (scan) length; and y=the absolute value of thelocation of the profile relative to the mean profile height (x-axis).

MELANODERM™ Assay: In other non-limiting aspects, the efficacy of eachof the active ingredients, any one of the combination of ingredients, orcompositions having said combinations disclosed in the specificationcompositions can be evaluated by using a skin analog, such as, forexample, MELANODERM™. Melanocytes, one of the cells in the skin analog,stain positively when exposed to L-dihydroxyphenyl alanine (L-DOPA), aprecursor of melanin. The skin analog, MELANODERM™, can be treated witha variety of bases containing each of the active ingredients, any one ofthe combination of ingredients, or compositions having said combinationsdisclosed in the specification or with the base alone as a control.Alternatively, an untreated sample of the skin analog can be used as acontrol.

All of the skin-active ingredients, compositions, or methods disclosedand claimed in this specification can be made and executed without undueexperimentation in light of the present disclosure. While theskin-active ingredients, compositions, or methods of this invention havebeen described in terms of particular embodiments, it will be apparentto those of skill in the art that variations may be applied to theskin-active ingredients, compositions, or methods and in the steps or inthe sequence of steps of the method described herein without departingfrom the concept, spirit and scope of the invention.

1-12. (canceled)
 13. A topical skin composition comprising: water; 1% to10% w/w glycerin; 1% to 10% w/w of a glycol; 1% to 10% w/w of a betaine;0.1% to 5% w/w C12-15 alkyl benzoate; 0.1% to 5% w/w dimethicone; 0.1%to 2% w/w triethanolamine; and 0.01% to 1% w/w disodium EDTA.
 14. Thetopical skin composition of claim 13, comprising 50% to 95% w/w water.15. The topical skin composition of claim 13, wherein the glycol ispropylene glycol and/or butylene glycol.
 16. The topical skincomposition of claim 13, wherein the betaine is betaine and/orcocamidopropyl betaine.
 17. The topical skin composition of claim 13,wherein the composition is formulated as a cream capable of reducing theappearance of dark circles or puffiness in the periorbital region of aperson's face.
 18. The topical skin composition of claim 17, furthercomprising: Butyrospermum parkii (shea) butter; hydrogenated polydecene;cetyl esters; dipalmitoyl hydroxyproline;phytosteryl/behenyl/octyldodecyl lauroyl glutamate; ceteareth-20;adenosine; and palmitoyl tetrapeptide-7.
 19. The topical skincomposition of claim 18, comprising: 1% to 10% w/w Butyrospermum parkii(shea) butter; 0.1% to 5% w/w hydrogenated polydecene; 0.1% to 5% w/wcetyl esters; 0.1% to 2% w/w dipalmitoyl hydroxyproline; 0.1% to 3% w/wphytosteryl/behenyl/octyldodecyl lauroyl glutamate; 0.01% to 1% w/wceteareth-20; 0.01% to 1% w/w adenosine; and 0.0001% to 0.1% w/wpalmitoyl tetrapeptide-7.
 20. The topical skin composition of claim 18,further comprising: polyethylene; ethylene/acrylic acid copolymer;behenyl alcohol; cetearyl glucoside; cetearyl alcohol; carbomer; andglyceryl polyacrylate.
 21. The topical skin composition of claim 20,comprising: 0.1% to 5% w/w polyethylene; 0.1% to 5% w/w ethylene/acrylicacid copolymer; 0.1% to 5% w/w behenyl alcohol; 0.1% to 5% w/w cetearylglucoside; 0.1% to 2% w/w cetearyl alcohol; 0.01% to 1% w/w carbomer;0.01% to 1% w/w hydroxypropyl cyclodextrin; 0.01% to 1% w/w glycerylpolyacrylate; and 0.01% to 1% w/w steareth-20.
 22. The topical skincomposition of claim 20, further comprising: phenoxyethanol;chlorphenesin; and iodopropynyl butylcarbamate.
 23. The topical skincomposition of claim 22, comprising: 0.1% to 3% phenoxyethanol; 0.01% to1% w/w chlorphenesin; and 0.001% to 0.1% w/w iodopropynylbutylcarbamate.
 24. The topical skin composition of claim 13, whereinthe composition is formulated as a skin cleanser.
 25. The topical skincomposition of claim 24, further comprising: TEA-lauryl sulfate;cocamidopropyl betaine; sodium methyl cocoyl taurate; PPG-26-buteth-26;and PEG-40 hydrogenated castor oil.
 26. The topical skin composition ofclaim 25, comprising: 1% to 15% w/w TEA-lauryl sulfate; 0.1% to 5% w/wcocamidopropyl betaine; 0.1% to 5% w/w sodium methyl cocoyl taurate;0.01% to 1% w/w PPG-26-buteth-26; and 0.01% to 1% w/w PEG-40hydrogenated castor oil.
 27. The topical skin composition of claim 25,further comprising: lauramine oxide; acrylates/C1-30 alkyl acrylatecrosspolymer; sodium chloride; and PEG-150 distearate.
 28. The topicalskin composition of claim 27, comprising: 0.1% to 3% w/w lauramineoxide; 0.1% to 3% w/w acrylates/C1-30 alkyl acrylate crosspolymer; 0.1%to 3% w/w sodium chloride; and 0.1% to 3% w/w PEG-150 distearate. 29.The topical skin composition of claim 27, further comprising:methylparaben and propylparaben.
 30. The topical skin composition ofclaim 29, comprising: 0.01% to 1% w/w methylparaben and 0.01% to 0.1%w/w propylparaben.
 31. A method of reducing the appearance of darkcircles or puffiness in the periorbital region of a person's face, themethod comprising topically applying the composition of claim 17 to skinin need thereof, wherein topical application reduces the appearance ofdark circles or puffiness in the periorbital region of a person's face.32. A method of cleansing a person's skin, the method comprisingtopically applying the composition of claim 24 to skin in need thereof,wherein topical application cleanses the skin of a person.